2. SBI-183

SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo .

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SBI-183 Chemical Structure

SBI-183 Chemical Structure

CAS No. : 625403-59-0

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SBI-183 Related Antibodies

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Description

SBI-183 is an orally active inhibitor of QSOX1 (Kd: 20 μM). SBI-183 suppresses the proliferative and invasive phenotype of renal cancer cell lines, including triple negative breast cancer cell line, lung adenocarcinoma cell line and pancreatic ductal adenocarcinoma. SBI-183 inhibits tumor growth in two human xenograft mouse models of renal cell carcinoma in vivo [1].

In Vitro

SBI-183 (6.25-50 μM, 15 min) inhibits the enzymatic activity of rQSOX1 in a dose-dependent manner[1].
SBI-183 inhibits proliferation of tumor cells, but does not kill fibroblasts or rapidly proliferating PBMC (0.625-20 μmol/L, 5 days), inhibits viability of 786-O, RCJ-41T2, and MDA-MB-231 with IC50 of 4.6 μM, 3.9 μM, and 2.4 μM, respectively (0.076 nM-40 μM, 72 h)[1].
SBI-183 (2.5-20 μmol/L, 4-8 days) inhibits tumor invasion in both 2D and 3D models of 786-O, RCJ-41T2, MDA-MB-231, A549 and MIA PaCa2 dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SBI-183 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: 786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
Concentration: 0.625, 1.25, 2.5, 5, 10, 20 μM
Incubation Time: 5 days
Result: Inhibited the growth of each tumor cell in a concentration-dependent manner.

Cell Invasion Assay[1]

Cell Line: 786-O, RCJ-41T2, MDA-MB-231, A549 和 MIA PaCa2
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 4, 6, 8 days
Result: Reduced invasion through Matrigel in each cell line.
In Vivo

SBI-183 (786-O: 400 μg/mouse/day, p.o., 35 days; RCJ-41T2: 100 mg/kg, p.o., 21 days) inhibits tumor growth in two independent human xenograft mouse models of renal cell carcinoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human xenograft mouse models of renal cell carcinoma (786-O and RCJ-41T2)[1]
Dosage: 400 μg/mouse/day (786-O); 100 mg/kg (RCJ-41T2)
Administration: Oral gavage (p.o.)
Result: Inhibited the growth of 786-O and RCJ-41T2 in vivo.
Reduced laminin-α4 deposition in RCJ-41T2 mouse xenografts.
Molecular Weight

296.36

Formula

C18H20N2O2
CAS No.
SMILES

O=C(C1=CC(OC)=CC=C1)NC2=CC=C(N3CCCC3)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SBI-183 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SBI-183625403-59-0SBI183SBI 183Breast cancer786-OMDA-MB-231A549MIA PaCa2Invasionrenal cell carcinomaInhibitorinhibitorinhibit

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