2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. SC4453

SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.

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SC4453 Chemical Structure

SC4453 Chemical Structure

CAS No. : 59712-21-9

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SC4453 Related Antibodies

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Description

SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.

Molecular Weight

822.98

Formula

C43H66O15
CAS No.
SMILES

O=C1OCC([C@H]2CCC3(O)[C@]4([H])CC[C@]5([H])C[C@@H](O[C@@H]6C[C@@H]([C@@H]([C@@H](C)O6)O[C@@H]7C[C@@H]([C@@H]([C@@H](C)O7)O[C@@H]8C[C@@H]([C@@H]([C@@H](C)O8)O)O)O)O)CC[C@]5(C)[C@@]4([H])C[C@@H](OC(C)=O)[C@]23C)=C1
Structure Classification
Initial Source

human heart
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SC4453 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC445359712-21-9SC 4453SC-4453Na+/K+ ATPaseSodium potassium pumpInhibitorinhibitorinhibit

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