2. Metabolic Enzyme/Protease
  3. Stearoyl-CoA Desaturase (SCD)
  4. SCD1 inhibitor-1

SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity.

For research use only. We do not sell to patients.

SCD1 inhibitor-1 Chemical Structure

SCD1 inhibitor-1 Chemical Structure

CAS No. : 1069094-65-0

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SCD1 inhibitor-1 Related Antibodies

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Description

SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity[1].

IC50 & Target

IC50: 8.8 nM (Recombinant human SCD1 enzyme)[1]
In Vivo

SCD1 inhibitor-1 (3-10 mg/kg; oral administration; 43 days) has an improved effect in high-fat mice models[1].
SCD1 inhibitor-1 (1-10 mg/kg; oral administration; single dose) has an improved effect in high-sucrose rat models[1].
Pharmacokinetic Analysis in rat and mouse[1]

Species Route Dose (mg/kg) Cmax (μM) tmax (h) t1/2 (h) AUC0-inf (μM·h) BA (%) Cltot (L/h/kg)
Rat p.o. 10 8.0 0.5 4.7 16.5 16 /
Mouse p.o. 10 1.7 1.0 5.2 10.2 28 /
Rat i.v. 1 / / / / / 0.21
Mouse i.v. 1 / / / / / 0.61

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice with high fat diet[1]
Dosage: 3 and 10 mg/kg
Administration: Oral administration (p.o.); 43 days
Result: Improved glucose tolerance in a dose-dependent manner and had a significant effect at a dose of 10 mg/kg.
Decreased body weight in a mild dose-dependent manner.
Animal Model: Sprague Dawley rats with high sucrose diet[1]
Dosage: 1 and 10 mg/kg
Administration: Oral administration (p.o.); Single dose
Result: Inhibited SCD1 inhibitory activity in a dose-dependent manner in epididymal adipose tissue and the liver 6 h after oral administration and to a lesser extent in the eyelid.
Had a selective tissue distribution of liver/eyelid.
Molecular Weight

451.54

Formula

C21H22N3NaO3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(CC(O[Na])=O)=CS1)C(S2)=CC=C2CNC3=CC=CC=C3CCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (18.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2146 mL 11.0732 mL 22.1464 mL
5 mM 0.4429 mL 2.2146 mL 4.4293 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.78%

SDS (252 KB)

COA (247 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2146 mL 11.0732 mL 22.1464 mL 55.3661 mL
5 mM 0.4429 mL 2.2146 mL 4.4293 mL 11.0732 mL
10 mM 0.2215 mL 1.1073 mL 2.2146 mL 5.5366 mL
15 mM 0.1476 mL 0.7382 mL 1.4764 mL 3.6911 mL
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SCD1 inhibitor-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCD1 inhibitor-11069094-65-0Stearoyl-CoA Desaturase (SCD)rats with high sucrose dietmice with high fat dietInhibitorinhibitorinhibit

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