Schizolaenone C

Cat. No.: HY-N11136: FAQs
Data Sheet Handling Instructions

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Schizolaenone C is a natural product that can be found in Schizolaena hystrix. Schizolaenone C exhibits anti-proliferative and anti-oxidative activities.

For research use only. We do not sell to patients.

Schizolaenone C Chemical Structure

CAS No. : 928760-56-9

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Description

Schizolaenone C is a natural product that can be found in Schizolaena hystrix. Schizolaenone C exhibits anti-proliferative and anti-oxidative activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
BJ	EC₅₀	7.5 μM Compound: 10	Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human BJ cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]
CCRF-CEM	EC₅₀	12.3 μM Compound: 10	Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human CEM cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]
HeLa	EC₅₀	6.3 μM Compound: 10	Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human HeLa cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]
MCF7	EC₅₀	< 10 μM Compound: 10	Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human MCF7 cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]
RPMI-8226	EC₅₀	7.1 μM Compound: 10	Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]
THP-1	EC₅₀	8.5 μM Compound: 10	Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method	[PMID: 20192247]
U-266	EC₅₀	1.9 μM Compound: 10	Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay Cytotoxicity against human U266 cells assessed as viable cells after 72 hrs by calcein AM assay	[PMID: 20192247]

In Vitro

Schizolaenone C inhibits the growth of A2780 human ovarian cells, with IC₅₀ of 21 μM^[1].
Schizolaenone C inhibits peroxynitrite induced tyrosine nitration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

424.49

Formula

C₂₅H₂₈O₆

CAS No.

928760-56-9

SMILES

C/C(C)=C\CC/C(C)=C/CC1=C(C=C2O[C@H](C3=CC(O)=CC(O)=C3)CC(C2=C1O)=O)O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Murphy BT, et, al. Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest. Planta Med. 2006 Oct;72(13):1235-8. [Content Brief]

[2]. Zima A, et, al. Antiradical and cytoprotective activities of several C-geranyl-substituted flavanones from Paulownia tomentosa fruit. Molecules. 2010 Aug 31;15(9):6035-49. [Content Brief]

Schizolaenone C Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Schizolaenone C928760-56-9OthersSchizolaena hystrixanti-proliferativeanti-oxidativeInhibitorinhibitorinhibit

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