Scospondistatin

Cat. No.: HY-P3995: FAQs
Data Sheet Handling Instructions

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Scospondistatin is an anti-angiogenic peptide that can inhibit proliferation and migration of human umbilical vein endothelial cells in vitro.

For research use only. We do not sell to patients.

Scospondistatin Chemical Structure

CAS No. : 929555-18-0

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Biological Activity
Purity & Documentation
References
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Description

Scospondistatin is an anti-angiogenic peptide that can inhibit proliferation and migration of human umbilical vein endothelial cells in vitro^[1].

In Vitro

Scospondistatin (0.01-40 μg/mL; 3 d) inhibits human umbilical vein endothelial cells (HUVECs) proliferation in a dose-dependent manner^[1].
Scospondistatin (30 μg/mL; 20 h) significantly inhibits the migration of HUVECs in the presence of VEGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	HUVECs
Concentration:	0.01, 0.1, 1, 10, 20, 30 and 40 μg/mL
Incubation Time:	3 days
Result:	Showed a monotonic dose response, with the anti-proliferative activity increasing with increasing the peptide concentration.

Cell Migration Assay ^[1]

Cell Line:	HUVECs
Concentration:	1, 10 and 30 μg/mL
Incubation Time:	20 h
Result:	Significantly inhibited the migration of HUVECs in the presence of VEGF at 30 μg/mL.

Molecular Weight

2023.17

Formula

C₈₁H₁₂₇N₂₇O₃₀S₂

CAS No.

929555-18-0

Sequence Shortening

GPWEDCSVSCGGGEQLRSR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Karagiannis ED, et al. Anti-angiogenic peptides identified in thrombospondin type I domains. Biochem Biophys Res Commun. 2007 Jul 20;359(1):63-9. [Content Brief]