Molecular Glue-like Compounds Library

Cat. No.: HY-L918

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-, VHL-, and DCAF-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 600 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Compound Screening Libraries

Download

Top Publications Citing Use of MedChemExpress (MCE) Products

Publications Citing Use of MedChemExpress (MCE) Products

Biological Activity
Product Details

Description & Advantages

• A unique collection of 600 molecular glue-like compounds is available for high throughput screening (HTS) and high content screening (HCS).

• A useful tool for conducting molecular glue research related to CRBN, VHL, and DCAF.

• All compounds are screened using AI and molecular docking technology, and they contain key pharmacophore features.

• All compounds are available off the shelf.

• LCMS or NMR validated to ensure high purity and quality.

Product Details

Formulation:

600 compounds obtained through AI screening and molecular docking, making it a valuable tool for the discovery of molecular glues.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

Related Service
Recommendation

Compound Customization

Specific Compounds
Quantities
Plate Map
Concentration
Form (Solid or Solution)
YES

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Container *

Remarks