SDH-IN-12 

SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC₅₀s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants^[1].

SDH-IN-12 (50 μM) exhibits fungicidal activities against S. sclerotiorum (98%), Alternaria solani (71%), B. cinerea (50%), R. solani (90%) and C. arachidicola (90%)^[1].
SDH-IN-12 (10 μM) destroys ultrastructure of S. sclerotiorum , resultes in contraction and obvious collapse of the mycelial surface^[1].
SDH-IN-12 reveals good bioavailability with a plasma protein binding ability (PPB) < 90%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

424.32

C₁₉H₁₃F₅N₄O₂

3027210-28-9

O=C(NC1=C(C2=CC(F)=C(F)C(F)=C2)C=CC=C1)NC(C3=CN(C)N=C3C(F)F)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sun NB, et al., Novel Pyrazole Acyl(thio)urea Derivatives Containing a Biphenyl Scaffold as Potential Succinate Dehydrogenase Inhibitors: Design, Synthesis, Fungicidal Activity, and SAR. J Agric Food Chem. 2024 Feb 7;72(5):2512-2525.  [Content Brief]