SDH-IN-14 

SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC₅₀=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane^[1].

SDH-IN-14 (0-100 μg/mL; 12 h) in B.cinerea reveals that cell membrane permeability increased with increasing concentration^[1].
SDH-IN-14 (0-200 μg/mL; 10 h) in B.cinerea shows an increase in MDA content with increasing concentration and oxidative damage to the cell membrane^[1].
SDH-IN-14 (12.5-100 μg/mL; 24 h) in B.cinerea shows a concentration-dependent inhibition of SDH activity^[1].
SDH-IN-14 shows antifungal activity of inhibition rat=96.7% (B.cinerea); 52.6% (R.solani); 69.9% (P.capsici); 59.2% (=S.sclerotiorum); 34.5% (=F.graminearum); 70.6% (Tomato Botrytis cinerea); 15.0% (=F.asiaticum), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SDH-IN-14 (100; 200 μg/mL) shows good antifungal activity on blueberry leaves, superior to Azoxystrobin (HY-B0849) and Fluopyram (HY-119459)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

424.54

C₂₁H₂₀N₄O₂S₂

O=C(NC1=NN=C(SCC(O)CN2C=CC3=C2C=CC=C3)S1)C4=CC=CC=C4C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. He B, et al. Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole. J Agric Food Chem. 2024 May 8;72(18):10227-10235.  [Content Brief]