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Icos

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  • HY-P76393
    B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His)

    Icos ligand; B7-H2; IcosLG; LIcos; B7RP-1; CD275

    		 Cynomolgus HEK293
    The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, His) is 256 a.a., with molecular weight of 50-70 KDa.
  • HY-P76394
    B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc)

    Icos ligand; B7-H2; IcosLG; LIcos; B7RP-1; CD275

    		 Cynomolgus HEK293
    B7-H2 is the ligand of Inducible Costimulator, was a ligand for CD28 and CTLA-4 in human, whereas these interactions were not conserved in mouse. B7-H2 interacted with CD28 in a non-overlapping domain. B7-H2 costimulation via CD28 induced survival factor Bcl-xL, downregulated cell cycle inhibitor p27kip1 and triggered signaling cascade of ERK and AKT kinases-dependent pathways. B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of B7-H2/ICOSLG Protein, Cynomolgus (HEK293, Fc) is 256 a.a., with molecular weight of ~53.3 KDa.

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