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LAIR1

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  • HY-P70871
    LAIR1 Protein, Mouse (HEK293, His)

    Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; mLAIR-1; CD305; LAIR1

    		 Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor that negatively regulates NK cells, B cells, and T cells. LAIR1 is activated by tyrosine phosphorylation, recruits PTPN6 and PTPN11, and exerts downstream inhibitory effects. LAIR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P74783
    LAIR1 Protein, Mouse (HEK293, Fc)

    Leukocyte-Associated Immunoglobulin-Like Receptor 1; LAIR-1; hLAIR1; CD305

    		 Mouse HEK293
    The LAIR1 protein functions as an inhibitory receptor, negatively regulating NK cells, B-cells, and T-cells. Activated by tyrosine phosphorylation, LAIR1 recruits PTPN6 and PTPN11, exerting downstream inhibitory effects. It diminishes intracellular calcium increase triggered by B-cell receptor ligation and independently modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG while inducing TGF-beta secretion. LAIR1 also regulates IgG and IgE production, inhibits proliferation, induces apoptosis in myeloid leukemia cells, prevents NF-kappa-B p65 subunit translocation, and inhibits I-kappa-B alpha phosphorylation. LAIR1 associates with SH2 domains of PTPN6 and PTPN11 and binds with high affinity to extracellular matrix collagens, signifying a functionally significant interaction. LAIR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived LAIR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LAIR1 Protein, Mouse (HEK293, Fc) is 112 a.a., with molecular weight of 49-53 kDa.

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