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CP 127374

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10211
    Tanespimycin
    45+ Cited Publications

    17-AAG; NSC 330507; CP 127374

    		 HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic Infection Cancer
    Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
    Tanespimycin
  • HY-10211R
    Tanespimycin (Standard)

    17-AAG (Standard); NSC 330507 (Standard); CP 127374 (Standard)

    		 HSP Autophagy Mitophagy Bacterial Apoptosis Antibiotic Infection Cancer
    Tanespimycin (Standard) is the analytical standard of Tanespimycin. This product is intended for research and analytical applications. Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90[1][5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression[3].
    Tanespimycin (Standard)