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Results for "

5-HT7R

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) G protein-coupled Bile Acid Receptor 1 (2)
By Research Areas:	Neurological Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-160887

FPT	5-HT Receptor	Neurological Disease
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT_1AR, a full agonist at 5-HT_1BR and 5-HT_1DR with EC₅₀s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at *5-HT₇R*. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models .

HY-139677

5-HT7R antagonist 1	G protein-coupled Bile Acid Receptor 1	Neurological Disease
5-HT7R antagonist 1 is a G protein-biased antagonist against *5-HT₇R* (K_i = 6.5 nM).

HY-139677A

5-HT7R antagonist 1 free base	G protein-coupled Bile Acid Receptor 1	Neurological Disease
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist against *5-HT₇R* (K_i = 6.5 nM).

HY-163345

5-HT7R antagonist 2

5-HT Receptor

Neurological Disease

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K_i of 67 nM, the IC₅₀ values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
Pharmacokinetic Analysis ICR Male Mice

药代动力学分析

Plasma	Intravenous Administration	Intraperitoneal Administration
T_max (h)	0.08	0.25
T_1/2 (h)	0.77	1.06
C_max (ng/mL)	33.07	156.44
AUC_last (ng·h/mL)	28.31	143.27
CL (L/h/kg)	41.61	-
V_ss (L/kg)	32.43	-
MRT (h)	0.79	0.93
F (%)	50.60

HY-159492

5-HT7 receptor ligand 2	5-HT Receptor	Neurological Disease
5-HT7 receptor ligand 2 (compound 32) is an arylpiperazinehydrazine ligand for *5-HT₇R* (K_i=178 nM). 5-HT7 receptor ligand 2 has good membrane permeability, low hepatotoxicity and cardiotoxicity, and high plasma protein binding. 5-HT7 receptor ligand 2 shows neuroprotective effects in SH-SY5Y cells and can be used for the study of central nervous system related diseases .

HY-145699

UCSF686	5-HT Receptor	Others
UCSF686 is a probe with which to study the function of the 5-HT_5AR. UCSF686 loses affinity at 5-HT_5AR (>10 000 nM) but not at 5-HT_1AR, 5-HT_2BR, and 5-HT₇R. UCSF686 controls for off-target effects .

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5-HT7R

Inhibitors & Agonists