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5-HT7R

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160887
    FPT

    		5-HT Receptor Neurological Disease
    FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT1AR, a full agonist at 5-HT1BR and 5-HT1DR with EC50s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT7R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models .
    FPT
  • HY-139677
    5-HT7R antagonist 1

    		G protein-coupled Bile Acid Receptor 1 Neurological Disease
    5-HT7R antagonist 1 is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM).
    5-HT7R antagonist 1
  • HY-159942
    5-HT7R antagonist 3

    		5-HT Receptor Dopamine Receptor Neurological Disease
    5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A) and 5786 nM (5-HT2A), respectively. 5-HT7R antagonist 3 possesses antidepressant and anxiolytic effects in mice .
    5-HT7R antagonist 3
  • HY-163345
    5-HT7R antagonist 2

    		5-HT Receptor Neurological Disease
    5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
    5-HT7R antagonist 2
  • HY-139677A
    5-HT7R antagonist 1 free base

    		G protein-coupled Bile Acid Receptor 1 Neurological Disease
    5-HT7R antagonist 1 (free base) is a G protein-biased antagonist against 5-HT7R (Ki = 6.5 nM).
    5-HT7R antagonist 1 free base
  • HY-159492
    5-HT7 receptor ligand 2

    		5-HT Receptor Neurological Disease
    5-HT7 receptor ligand 2 (compound 32) is an arylpiperazinehydrazine ligand for 5-HT7R (Ki=178 nM). 5-HT7 receptor ligand 2 has good membrane permeability, low hepatotoxicity and cardiotoxicity, and high plasma protein binding. 5-HT7 receptor ligand 2 shows neuroprotective effects in SH-SY5Y cells and can be used for the study of central nervous system related diseases .
    5-HT7 receptor ligand 2
  • HY-145699
    UCSF686

    		5-HT Receptor Others
    UCSF686 is a probe with which to study the function of the 5-HT5AR. UCSF686 loses affinity at 5-HT5AR (>10 000 nM) but not at 5-HT1AR, 5-HT2BR, and 5-HT7R. UCSF686 controls for off-target effects .
    UCSF686
  • HY-173044
    5-HT1AR/5-HT6R ligand-1

    		5-HT Receptor Dopamine Receptor Neurological Disease
    5-HT1AR/5-HT6R ligand-1 (Compound PP13) is the ligand for 5-HT receptor that exhibits good affinity to 5-HT1AR, 5-HT6R and 5-HT7R (Ki of 19, 69 and 198 nM, respectively), thereby inhibiting the cAMP production in HEK293 cell with EC50 of 1535, 488 and 53 nM, respectively. 5-HT1AR/5-HT6R ligand-1 exhibits anti-proliferative activity against a variety of cancer cells (IC50 for 1321N1, U87MG, MCF7, and AsPC-1 is 9.6, 13.6, 19.3 and 14.6 μM, respectively). 5-HT1AR/5-HT6R ligand-1 also exhibits antagonist activity for dopamine receptor D2R with Ki of 1903 nM .
    5-HT1AR/5-HT6R ligand-1
  • HY-146201
    PDE4B/7A-IN-1

    		Phosphodiesterase (PDE) 5-HT Receptor Neurological Disease
    PDE4B/7A-IN-1 (compound 7) is a PDE4B/PDE7A inhibitor (PDE4B, IC50=80.4 μM) and 5-HT1A/5-HT-7R antagonist. PDE4B/7A-IN-1 has membrane-penetrating activity and high metabolic stability. PDE4B/7A-IN-1 exhibits antidepressant properties in rat behavioral tests .
    PDE4B/7A-IN-1

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