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AMF

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By Targets:	Amino Acid Derivatives (1) Apoptosis (2) DNA/RNA Synthesis (2) PKA (1) PKC (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (3)

4

Inhibitors & Agonists

1

Peptides

3

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PBA-AMF	Apoptosis DNA/RNA Synthesis	Cancer
PBA-AMF can be activated by H₂O₂ to release Amonafide (AMF) (HY-10982). PBA-AMF selectively inhibited the proliferation of breast cancer cells, while sparing non-cancerous cells. PBA-AMF inhibits tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBA-AMF can be used for research of tumors and other diseases associated with increased H₂O₂ levels .

PBE-AMF	Apoptosis DNA/RNA Synthesis Reactive Oxygen Species	Cancer
PBE-AMF is a prodrug that activates H₂O₂ with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells (IC₅₀=6.4 μM) while sparing non-cancerous MCF-10A cells .

Protein kinase inhibitor 7	PKC PKA	Cancer
Protein kinase inhibitor 7 is an inhibitor for protein kinase A and protein kinase C. Protein kinase inhibitor 7 affects autocrine motility factor (AMF) signaling pathway, without affecting the cell motility .

Fmoc-D-4-Aph(cBm)-OH	Amino Acid Derivatives	Others
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .

Cat. No.	Product Name	Target	Research Area

Fmoc-D-4-Aph(cBm)-OH	Amino Acid Derivatives	Others
Fmoc-D-4-Aph(cBm)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize biologically active peptide mimetics, such as Ac-D2Nal-D4Cpa-D3Pal-Ser-4Aph/4Amf(P)-D4Aph/D4Amf(Q)-Leu-ILys-Pro-DAla-NH2 with gonadotropin-releasing hormone (GnRH) antagonist activity .

Species:	Human (1) Mouse (2)
Tag:	His (3) B2M (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) Gpi; Gpi1Glucose-6-phosphate isomerase; GPI; AMF; Neuroleukin; NLK; PHI	Mouse	P. pastoris
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by P. pastoris , with N-6*His labeled tag.

	Glucose-6-phosphate isomerase Protein, Human (His) AMF; Aurocrine motility factor; Autocrine motility factor; DKFZp686C13233; EC 5.3.1.9; Neuroleukin; NLK; Oxoisomerase; PGI; PHI; Phosphoglucose isomerase; SA-36; SA36; Sperm antigen 36	Human	E. coli
	Glucose-6-phosphate isomerase protein is a key player in glycolysis, catalyzing the conversion of glucose-6-phosphate into fructose-6-phosphate in the cytoplasm. It carries out this reaction reversibly during gluconeogenesis. Glucose-6-phosphate isomerase Protein, Human (His) is the recombinant human-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His labeled tag.

	Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) Gpi; Gpi1Glucose-6-phosphate isomerase; GPI; EC 5.3.1.9; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI	Mouse	E. coli
	Glucose-6-phosphate isomerase protein exists in the cytoplasm and has dual functions. It converts glucose-6-phosphate into fructose-6-phosphate, playing a vital role in glycolysis and gluconeogenesis. Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is the recombinant mouse-derived Glucose-6-phosphate isomerase protein, expressed by E. coli , with N-6*His, B2M labeled tag. The total length of Glucose-6-phosphate isomerase Protein, Mouse (His-B2M) is 557 a.a., with molecular weight of ~76.6 kDa.

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Cat. No.	Compare	Product Name	Application	Reactivity

	AMF Antibody (YA1777) GPI; Glucose-6-phosphate isomerase; GPI; Autocrine motility factor; AMF; Neuroleukin; NLK; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI; Sperm antigen 36; SA-36	WB, IHC-P, ICC/IF, FC	Human
	AMF Antibody (YA1777) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1777), targeting AMF, with a predicted molecular weight of 63 kDa (observed band size: 63 kDa). AMF Antibody (YA1777) can be used for WB, IHC-P, ICC/IF, FC experiment in human background.

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