ATIC

By Targets:	Autophagy (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fungal (2) Mitophagy (1) Opioid Receptor (1) PROTAC Linkers (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150252A

ATIC-IN-1 acetate	Endogenous Metabolite	Cancer
ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to *Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization* with a K_i value of 685 nM, whcich catalyzes de novo purine biosynthesis. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-N0485

Liensinine Diperchlorate 5+ Cited Publications	Autophagy Mitophagy	Cardiovascular Disease
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-P990067

Evunzekibart ATOR-1017	TNF Receptor	Cancer
Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.

HY-N1448

Vincetoxicoside B	Fungal	Infection
Vincetoxicoside B shows antifungal activity .

HY-150252

ATIC-IN-1	Others	Cancer
ATIC-IN-1(compound 14) is an inhibitor targeting to *Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization* with a K_i value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates .

HY-29244

ATIC-IN-2	DNA/RNA Synthesis	Cancer
ATIC-IN-2 (Compound 1) is a competitive inhibitor for the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), that binds to inosine monophosphate cyclohydrolase (IMPCH) with a K_i of 0.13 μM .

HY-RS01156

ATIC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATIC Human Pre-designed siRNA Set A contains three designed siRNAs for ATIC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATIC Human Pre-designed siRNA Set A ATIC Human Pre-designed siRNA Set A

HY-RS17124

Atic Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Atic Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atic Mouse Pre-designed siRNA Set A Atic Mouse Pre-designed siRNA Set A

HY-RS01126

ATE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATE1 Human Pre-designed siRNA Set A ATE1 Human Pre-designed siRNA Set A

HY-N1448R

Vincetoxicoside B (Standard)	Fungal	Infection
Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity .

HY-141324

*Tetraethyl butane-1,4-diylbis(phosphoramidate)*	PROTAC Linkers	Cancer
Tetraethyl butane- 1, 4- diylbis(phosphoramid ate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-E70121

Succinyl-CoA synthetase	Others	Others
Succinyl-CoA synthetase catalyzes the only substrate-level phosphoryl-ation step in the tricarboxylic acid cycle. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism .

HY-135238

(rel)-RSD 921 PD-117302	Opioid Receptor	Others
(rel)-RSD 921 (PD-117302) is a κ-opioid receptor agonist. (rel)-RSD 921 did not have a greater food-inducing effect in obese than in lean Zucker rats; in both obese and lean Zucker rats, lean rats were more sensitive to its initial food-inducing effect but ultimately ate less.

Cat. No.	Product Name	Target	Research Area

HY-P990067

Evunzekibart ATOR-1017	TNF Receptor	Cancer
Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart can be used as monotherapy or in combination with anti-PD1 to exert anticancer activity.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0485

Liensinine Diperchlorate 5+ Cited Publications	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Phenols Polyphenols Nelumbo nucifera Gaertn. Plants Disease Research Fields Nymphaeaceae	Autophagy Mitophagy
Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc .

HY-N1448

Vincetoxicoside B	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Erythrina stricta Roxb. Plants Compositae Disease Research Fields	Fungal
Vincetoxicoside B shows antifungal activity .

HY-N1448R

Vincetoxicoside B (Standard)	Flavonols Structural Classification Flavonoids Source classification Phenols Polyphenols Erythrina stricta Roxb. Plants Compositae	Fungal
Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81327

	ATIC Antibody (YA1072) PURH; AICAR; AICARFT; IMPCHASE	WB	Human, Mouse, Rat
	ATIC Antibody (YA1072) is a non-conjugated IgG1 antibody, targeting ATIC, with a predicted molecular weight of 65 kDa (observed band size: 65 kDa). ATIC Antibody (YA1072) can be used for WB experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS01156

ATIC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATIC Human Pre-designed siRNA Set A contains three designed siRNAs for ATIC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17124

Atic Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Atic Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atic gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01126

ATE1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ATE1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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