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Results for "

AURKA-IN-1

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161407
    AURKA-IN-1

    		Aurora Kinase Cancer
    AURKA-IN-1 (compound 9) is an cell-active covalent AURKA inhibitor. AURKA-IN-1 is a lysine-reactive activity probe [1].
    AURKA-IN-1
  • HY-155464
    VEGFR-2/AURKA-IN-1

    		VEGFR Aurora Kinase Cancer
    VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential [1].
    VEGFR-2/AURKA-IN-1
  • HY-162837
    AURKA against 1

    		Aurora Kinase Cancer
    AURKA against 1 is an inhibitor of AURKA (IC50 less than 0.5 nM), targeting endogenous lysine (K162) acetylation, and has anti-proliferation activity against tumor cells. AURKA against 1 induces K162 acetylation, and the kinase activity of AURKA is reversibly restored in HCT116 cells transfected with SIRT3 [1].
    AURKA against 1
  • HY-158038
    AurkA allosteric-IN-1

    		Aurora Kinase Cancer
    AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA [1].
    AurkA allosteric-IN-1

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