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Afegostat

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14829
    Afegostat

    D-Isofagomine; Isofagomine

    		 Glycosidase Neurological Disease
    Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat
  • HY-14829E
    Afegostat D-Tartrate

    D-Isofagomine D-Tartrate; Isofagomine D-Tartrate

    		 Glycosidase Neurological Disease
    Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat D-Tartrate
  • HY-14829B
    Afegostat tartrate

    AT 2101; D-Isofagomine tartrate; Isofagomine tartrate

    		 Glycosidase Neurological Disease
    Afegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat tartrate
  • HY-14829A
    Afegostat hydrochloride

    D-Isofagomine hydrochloride; Isofagomine hydrochloride

    		 Glycosidase Metabolic Disease
    Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells .
    Afegostat hydrochloride
  • HY-14829H
    Afegostat TFA

    		Glycosidase Neurological Disease
    Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
    Afegostat TFA
  • HY-14829F
    L-Afegostat

    5-epi-Isofagomine

    		 Glycosidase Metabolic Disease
    L-Afegostat (5-epi-Isofagomine) is a glycosidase inhibitor. L-Afegostat is an iminosugar that can be used for the synthesis of carbohydrates. L-Afegostat shows enzyme inhibition to β-Glucosidase with an Ki of 30 μM .
    L-Afegostat