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Results for "

BCAT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminotransferases (Transaminases) (2) Fluorescent Dye (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BAY-069 2 Publications Verification	Fluorescent Dye	Cancer
BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and *BCAT2* inhibitor with IC₅₀ values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer ^[1].

BAY-252	Fluorescent Dye	Cancer
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and *BCAT2* inhibitor with IC₅₀s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer ^[1].

ERG240 3 Publications Verification	Others	Inflammation/Immunology Cancer
ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease ^[1].

BCATc Inhibitor 2 4 Publications Verification	Aminotransferases (Transaminases)	Neurological Disease
BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC₅₀s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm ^[1].

BCAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
BCAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCAT1 Human Pre-designed siRNA Set A BCAT1 Human Pre-designed siRNA Set A

ERG245	Aminotransferases (Transaminases)	Cancer
ERG245 is a *BCAT1* inhibitor that enhances oxidative phosphorylation (OXPHOS) in CD8 ⁺ T cells by specifically inhibiting *BCAT1* activity, thereby increasing the cytotoxicity of CD8 ⁺ T cells. ERG245, in combination with Pembrolizumab (anti-PD-1, HY-P9902A), promotes tumor regression. ERG245 can be used in research related to immuno-oncology ^[1].

BAY-771	Fluorescent Dye	Metabolic Disease Cancer
BAY-771, a structurally close pyrimidinedione, is a chemical probe with good lead-like properties and high permeability in Caco-2 cells (no hint of efflux). BAY-771 shows very weak inhibitory activity in the BCAT1 biochemical assay and no activity in BCAT2. BAY-771 can be used as a negative control of HY-148242 BAY-069. BAY-771 can be used for the research of tumor metabolism ^[1].

Cat. No.	Compare	Product Name	Species	Source

	BCAT1 Protein, Human BCAT1; Branched-chain-amino-acid aminotransferase; cytosolic; BCAT(c); Protein ECA39	Human	E. coli
	The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human is the recombinant human-derived BCAT1 protein, expressed by E. coli , with tag free. The total length of BCAT1 Protein, Human is 385 a.a., .

	BCAT1 Protein, Human (His, StrepⅡ) BCAT1; Branched-chain-amino-acid aminotransferase; cytosolic; BCAT(c); Protein ECA39	Human	E. coli
	The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human (His, Strep) is the recombinant human-derived BCAT1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of BCAT1 Protein, Human (His, Strep) is 385 a.a., .

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BCAT1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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