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C48/80 trihydrochloride

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130592
    Compound 48/80 trihydrochloride

    C48/80 trihydrochloride

    		 Phospholipase Neurological Disease
    Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
    Compound 48/80 trihydrochloride
  • HY-158990
    GE1111

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    GE1111 is the antagonist for mas-related G protein-coupled receptor X2 (MRGPRX2) with an IC50 of 9.42 μM. GE1111 inhibits mast cell degranulation with an IC50 of 4.7 μM. GE1111 exhibits anti-allergic and anti-inflammatory effects in C48/80 (HY-130592)-induced systemic allergic reaction model .
    GE1111
  • HY-172458
    Z-3578

    		Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor Neurological Disease
    Z-3578 is a small-molecule antagonist targeting MrgX2 (Mas-related G protein-coupled receptor X2) with significant anti-pseudoallergic activity and a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppressing the release of β-hexosaminidase with IC50 values of 4.90 µM and 6.18 µM, respectively. It also markedly reduces the release of histamine and TNF-α, along with intracellular calcium flux. In a murine pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation and lowers serum histamine levels, indicating potent in vivo anti-allergic effects. Z-3578 holds promise as a lead compound for the treatment of allergic diseases, especially pseudoallergic reactions .
    Z-3578

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