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Results for "

CBR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Apoptosis (5) Autophagy (2) CCR (1) COX (1) Endogenous Metabolite (4) HIF/HIF Prolyl-Hydroxylase (1) NF-κB (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155587

Hydroxy-PP	Others	Cancer
Hydroxy-PP is a potent CBR1 inhibitor with an IC₅₀ value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC₅₀ value of 5 nM ^[1].

HY-13930

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

HY-RS02004

CBR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CBR1 Human Pre-designed siRNA Set A CBR1 Human Pre-designed siRNA Set A

HY-157448

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a *CBR1* inhibitor with chemosensitizing and cardioprotective activities ^[1].

HY-157449

CBR1-IN-5	Others	Cancer
CBR1-IN-5 (compound 13o) is a potent inhibitor of *CBR1* with an IC₅₀ of 0.1 μM ^[1].

HY-157451

CBR1-IN-7	Others	Cancer
CBR1-IN-7 (Compound JV-2) is a human *CBR1* inhibitor (IC₅₀=8 μM). CBR1-IN-7 can be used in cancer research ^[1].

HY-157447

CBR1-IN-4	Others	Cancer
CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC₅₀=0.09 μM). CBR1-IN-4 can be used in cancer research ^[1].

HY-157445

CBR1-IN-3	Others	Metabolic Disease
CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM ^[1].

HY-121710

MonoHER 7-Monohydroxyethylrutoside	Others	Cardiovascular Disease
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner ^[1].

HY-157450

YF-Mo1	Apoptosis	Cancer
YF-Mo1 (compound 9) is a *CBR1* inhibitor with an IC₅₀ value of 1.1 μM ^[1].

HY-157452

(8S)-Methyl zearalenone	Others	Cancer
(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC₅₀ of 0.21 μM ^[1].

HY-13930R

Miquelianin (Standard)	Endogenous Metabolite	Cancer
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

HY-156694

Hydroxy-PP-Me	Apoptosis	Cancer
Hydroxy-PP-Me is a potent and specific *CBR1* inhibitor with an IC₅₀ of 759 nM. Hydroxy-PP-Me inhibits serum-withdrawal-induced apoptosis. Hydroxy-PP-Me increases As₂O₃-induced apoptotic cell death compared with As₂O₃ alone ^[1] .

HY-157444

5,3',4',3'',4'',5''-6-O-Ethyl-EGCG	HIF/HIF Prolyl-Hydroxylase	Cancer
5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) is a potent adjuvant obtained by optimization of the structure of EGCG. 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) decreases the expression of *HIF-1α* and *CBR1* at both the mRNA and protein levels ^[1].

HY-N0148

Rutin Maximum Cited Publications 11 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

HY-N0148R

Rutin (Standard)	Amyloid-β Autophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM ^[1].

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Flavonols Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Endogenous Metabolite
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a *CBR1* inhibitor.

Rutin Maximum Cited Publications 11 Publications Verification Rutoside; Quercetin 3-O-rutinoside	Flavonols Structural Classification Classification of Application Fields Source classification Plants Flavonoids other families Leguminosae Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and *CBR1* inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production ^[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM ^[1].

Miquelianin (Standard)	Flavonols Structural Classification Flavonoids Microorganisms other families Source classification Phenols Polyphenols Plants Endogenous metabolite	Endogenous Metabolite
Miquelianin (Standard) is the analytical standard of Miquelianin. This product is intended for research and analytical applications. Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

Rutin (Standard)	Flavonols Structural Classification Flavonoids other families Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Autophagy Apoptosis Endogenous Metabolite
Rutin (Standard) is the analytical standard of Rutin. This product is intended for research and analytical applications. Rutin (Rutoside) is a flavonoid found in many plants and shows a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective and reducing Aβ oligomer activities. Rutin is also a *CBR1* inhibitor, which can cross the blood brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis via suppression of apoptosis, mitochondrial dysfunction, and oxidative stress ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P72272

	CBR1 Protein, Human (P.pastoris, His) Carbonyl Reductase 1; SDR21C1	Human	P. pastoris
	CBR1 is an NADPH-dependent reductase with broad substrate specificity and plays a key role in the reduction of various carbonyl compounds, including quinones, prostaglandins, menadione, and xenobiotics. Crucially, CBR1 converts the anthracyclines doxorubicin and daunorubicin into their cardiotoxic forms doxorubicin and daunorubicin. CBR1 Protein, Human (P.pastoris, His) is the recombinant human-derived CBR1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CBR1 Protein, Human (P.pastoris, His) is 276 a.a., with molecular weight of ~33.0 kDa.

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HY-P80590

	CBR1 Antibody (YA810) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreduc	WB, ICC/IF	Human
	CBR1 Antibody (YA810) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to CBR1 (2C9). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

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CBR1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
CBR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CBR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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