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CK2α-IN-1

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By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) c-Kit (1) Casein Kinase (2) CDK (1) Checkpoint Kinase (Chk) (1) EGFR (1) Pim (1) Trk Receptor (1)
By Research Areas:	Cancer (2)

Targets Recommended: AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*CK2α-IN-1*	Casein Kinase	Cancer
CK2α-IN-1 (compound 2) is a selective *CK2α* inhibitor (IC₅₀=7.0 µM; K_i=1.6 µM) that exhibits a non-ATP-competitive mode of action. CK2α-IN-1 exhibits good potential for anticancer studies .

Multi-kinase-IN-6	Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis	Cancer
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, *CK2α, CHK1*, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC₅₀ values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect .

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