Search Result
Results for "
Candida cells
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-N10113
-
Muconomycin B
|
Apoptosis
Arenavirus
Fungal
Antibiotic
Reactive Oxygen Species
|
Infection
Cancer
|
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC50 of 1.2 ng/mL .
|
-
-
- HY-102069
-
|
Polo-like Kinase (PLK)
CDK
DAPK
|
Others
|
3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 (Plk1) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 μM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division .
|
-
-
- HY-Y0248A
-
-
-
- HY-Y0248AS
-
-
-
- HY-B0139
-
5-Fluorocytosine; NSC 103805; Ro 2-9915
|
Fungal
Antibiotic
|
Infection
Cancer
|
Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
|
-
-
- HY-146116
-
|
Fungal
|
Infection
|
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .
|
-
-
- HY-143335
-
|
Fungal
|
Infection
|
Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .
|
-
-
- HY-149822
-
|
Fungal
|
Infection
|
Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity .
|
-
-
- HY-125152
-
CndD
|
Antibiotic
Fungal
|
Infection
|
Candicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
|
-
-
- HY-Y0248AR
-
|
Endogenous Metabolite
Bacterial
Antibiotic
|
Infection
Cancer
|
Farnesol (Standard) is the analytical standard of Farnesol. This product is intended for research and analytical applications. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
|
-
-
- HY-147970
-
|
Fungal
|
Infection
|
Antifungal agent 34 (compound 6i) is a potent antifungal agent. Antifungal agent 34 shows a potent antifungal activity against Candida albicans, with a MIC of 4 µg/mL. Antifungal agent 34 shows significant inhibition on Candida albicans hyphae and biofilm development. Antifungal agent 34 exhibits no cytotoxicity to mammalian cells .
|
-
-
- HY-P5647
-
|
Bacterial
|
Infection
|
PhD1 is an antimicrobial peptide derived from monkey white blood cells. PhD1 has activity against bacteria and fungus Candida albicans .
|
-
-
- HY-P5648
-
|
Bacterial
|
Infection
|
PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .
|
-
-
- HY-P5649
-
|
Bacterial
|
Infection
|
PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .
|
-
-
- HY-P5651
-
|
Bacterial
|
Infection
|
PhD4 is an antimicrobial peptide derived from monkey white blood cells. PhD4 has activity against bacteria and fungus Candida albicans .
|
-
-
- HY-124701
-
|
Fungal
|
Infection
|
Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect .
|
-
-
- HY-B0139R
-
5-Fluorocytosine (Standard); NSC 103805 (Standard); Ro 2-9915 (Standard)
|
Fungal
Antibiotic
|
Infection
Cancer
|
Flucytosine (Standard) is the analytical standard of Flucytosine. This product is intended for research and analytical applications. Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells .
|
-
-
- HY-N3307
-
-
-
- HY-163462
-
|
Fungal
|
Infection
|
Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants .
|
-
-
- HY-156252
-
|
Fungal
|
Infection
|
Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .
|
-
-
- HY-P10408
-
|
EGFR
MMP
Calcium Channel
|
Infection
Inflammation/Immunology
|
Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candida albicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase (MMP) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells .
|
-
-
- HY-121407
-
|
Acyltransferase
|
Infection
Cancer
|
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .
|
-
-
- HY-P10304
-
Cyclo(Pro-Arg)
|
Fungal
|
Others
|
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candida albicans from yeast form to filamentous form .
|
-
-
- HY-P2450
-
Antibiotic P168
|
Fungal
Antibiotic
|
Infection
Cancer
|
Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies .
|
-
-
- HY-P10304A
-
Cyclo(Pro-Arg) TFA
|
Parasite
|
Infection
|
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) TFA is a chitinase inhibitor. Cyclo(Arg-Pro) TFA inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) TFA inhibits the morphological change of Candida albicans from yeast form to filamentous form .
|
-
-
- HY-170394
-
|
Bacterial
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
Apoptosis inducer 33 (Compound H2) is a hydrazone derivative. Apoptosis inducer 33 has antioxidant and antibacterial activity that inhibits the growth of Staphylococcus aureus, Escherichia coli and Candida albicans. Apoptosis inducer 33 inhibits tumor cells proliferation and induces apoptosis, which can be used in the study of cancer .
|
-
-
- HY-129260
-
3-Amino-3-deoxyglucose
|
Fungal
|
Infection
|
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candida albicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
|
-
-
- HY-W012126
-
2,6-Dichloro-N-phenylaniline
|
Bacterial
|
Infection
Cancer
|
2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
-
- HY-N13025
-
Verrucarin L acetate
|
Fungal
|
Infection
|
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum .
|
-
-
- HY-P10795
-
Antibiotic NK 2
|
Parasite
Bacterial
Fungal
|
Infection
|
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
|
-
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
-
- HY-N12264
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
|
-
-
- HY-N12606
-
|
Fungal
|
Infection
|
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
|
-
-
- HY-B0852
-
|
Cytochrome P450
Fungal
Apoptosis
|
Infection
|
Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
|
-
-
- HY-A0059
-
NF 113; SAP 113; Methylmercadone
|
Bacterial
Parasite
Antibiotic
Fungal
Apoptosis
STAT
Interleukin Related
TNF Receptor
|
Infection
Inflammation/Immunology
Cancer
|
Nifuratel (NF 113) is an orally active broad-spectrum antibiotic with antiprotozoal, antibacterial, anticancer and anti-inflammatory activities, and has good inhibitory effects on Candida and Trichomonas. Nifuratel is also a STAT3 inhibitor, which significantly inhibits the growth and proliferation of human gastric cancer cells and induces apoptosis. In addition, Nifuratel also inhibits mast cell-mediated antigen hypersensitivity reactions and can be used in the study of IgE-mediated allergic diseases .
|
-
-
- HY-138074
-
5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime
|
Parasite
|
Infection
|
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL). Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
|
-
-
- HY-W012088
-
Myristoleic acid methyl ester; Methyl myristoleate; cis-9-Tetradecenoate methyl ester
|
Others
|
Infection
|
(Z)-Methyl tetradec-9-enoate (Myristoleic acid methyl ester; Methyl myristoleate) is a cytotoxic component extracted from S. repens fruit extract. It induces apoptosis and necrosis in human prostate cancer LNCaP cells. In addition, (Z)-Methyl tetradec-9-enoate found in cheese-making byproducts inhibits Candida albicans germination with a minimum inhibitory concentration (MIC) of 9 μM in vivo.
|
-
-
- HY-118843
-
|
Potassium Channel
|
Infection
|
Lombazole is an antimicrobial compound with activity that inhibits cell membrane synthesis. Lombazole had little effect on K+ permeability in S. aureus. Lombazole inhibited only de novo synthesis of cell enclosure in S. aureus, and this effect occurred before growth was affected. The main effect of lombazole was through inhibition of lipid synthesis. Lombazole may have an effect on key steps in lipid biosynthesis, as inferred from the lack of changes in lipid patterns after treatment. Lombazole also inhibited the sterol C-14 demethylation step in Candida albicans .
|
-
-
- HY-P2313
-
HβD-2
|
Antibiotic
Bacterial
|
Infection
|
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
|
-
-
- HY-W068682
-
Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin
|
Amylases
Bacterial
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
|
-
-
- HY-W012126R
-
2,6-Dichloro-N-phenylaniline (Standard)
|
Bacterial
|
Infection
Cancer
|
2,6-Dichlorodiphenylamine (Standard) is the analytical standard of 2,6-Dichlorodiphenylamine. This product is intended for research and analytical applications. 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
-
- HY-B0852R
-
|
Cytochrome P450
Fungal
Apoptosis
|
Infection
|
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
|
-
-
- HY-168204
-
|
Bacterial
Fungal
|
Infection
|
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .
|
-
-
- HY-164999
-
|
Endogenous Metabolite
|
Cancer
|
N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a enterochelin hydrolyzed product. N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candida albicans .
|
-
-
- HY-116686
-
|
Cytochrome P450
Fungal
|
Infection
|
Inz-1 is a potent and selective mitochondrial cytochrome bc1 inhibitor for yeast (IC50=8.092 μM) over humans (IC50=45.320 μM). Inz-1 reverses Fluconazole (HY-B0101) or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans .
|
-
-
- HY-10863
-
-
-
- HY-158402
-
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
|
-
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10408
-
|
EGFR
MMP
Calcium Channel
|
Infection
Inflammation/Immunology
|
Candidalysin is a cytolytic peptide toxin, which is initially isolated from Candida albicans and exhibits virulent and avirulent characters. Candidalysin activates epithelial cell signaling pathways by interacting with the epithelial growth factor receptor (EGFR) of host cells, activates matrix metalloproteinase (MMP) and calcium flux, resulting in inflammatory responses and recruitment of immune cells. Candidalysin exhibits cytotoxicity by dealing membran damage to host cells .
|
-
- HY-P10304A
-
Cyclo(Pro-Arg) TFA
|
Parasite
|
Infection
|
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) TFA is a chitinase inhibitor. Cyclo(Arg-Pro) TFA inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) TFA inhibits the morphological change of Candida albicans from yeast form to filamentous form .
|
-
- HY-P10603
-
|
Peptides
|
Infection
|
SP1 is an α-peptide encoded by the mating pheromone MFα1 gene in Candida albicans, which can induce cell growth arrest at the mating type locus MTLa in Candida albicans. SP1 can be used in the study of the prevention and treatment of Candida albicans infection .
|
-
- HY-P5647
-
|
Bacterial
|
Infection
|
PhD1 is an antimicrobial peptide derived from monkey white blood cells. PhD1 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5648
-
|
Bacterial
|
Infection
|
PhD2 is an antimicrobial peptide derived from monkey white blood cells. PhD2 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5649
-
|
Bacterial
|
Infection
|
PhD3 is an antimicrobial peptide derived from monkey white blood cells. PhD3 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P5651
-
|
Bacterial
|
Infection
|
PhD4 is an antimicrobial peptide derived from monkey white blood cells. PhD4 has activity against bacteria and fungus Candida albicans .
|
-
- HY-P10604
-
|
Peptides
|
Others
|
SP2 is a 14-amino acid long active peptide that can induce growth arrest in MTLa cells of the mating type locus of Candida albicans .
|
-
- HY-P10304
-
Cyclo(Pro-Arg)
|
Fungal
|
Others
|
Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candida albicans from yeast form to filamentous form .
|
-
- HY-P10795
-
Antibiotic NK 2
|
Parasite
Bacterial
Fungal
|
Infection
|
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .
|
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
- HY-P2313
-
HβD-2
|
Antibiotic
Bacterial
|
Infection
|
Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida, but not gram-positive Staphylococcus aureus . Human β-defensin-2 can be used for the study of colitis .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N10113
-
-
-
- HY-Y0248A
-
-
-
- HY-N3307
-
-
-
- HY-10863
-
-
-
- HY-Y0248AR
-
-
-
- HY-P2450
-
-
-
- HY-129260
-
3-Amino-3-deoxyglucose
|
Microorganisms
Source classification
|
Fungal
|
Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candida albicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma .
|
-
-
- HY-N13025
-
Verrucarin L acetate
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Fungal
|
8-Acetylverrucarin L (Verrucarin L acetate) is a mycotoxin, which exhibits antitumor and antimicrobial activities. 8-Acetylverrucarin L exhibits cytotoxicity to cancer cells HCT116 and A2780S, with IC100 of 9.77 and 9.77 ng/mL. 8-Acetylverrucarin L exhibits antifungal activity against Saccharomyces cerevisiae, Candida albicans and Geotrichum candidum .
|
-
-
- HY-N12264
-
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Antibiotic
Bacterial
Fungal
|
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
|
-
-
- HY-N12606
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-Y0248AS
-
|
(E,E)-Farnesol-d6 is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
|
-
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- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent: