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Clickable Probes

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43

Inhibitors & Agonists

17

Fluorescent Dye

1

Biochemical Assay Reagents

2

Peptides

38

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151761
    H-L-Lys(4-N3-Z)-OH hydrochloride

    		ADC Linker Others
    H-L-Lys(4-N3-Z)-OH hydrochloride is a click chemistry reagent containing an azide group. H-L-Lys(4-N3-Z)-OH hydrochloride contains a lysine-modified azide moiety and as a bioorthogonal ligation handle. H-L-Lys(4-N3-Z)-OH hydrochloride is an infrared probe and a photo-affinity reagent . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    H-L-Lys(4-N3-Z)-OH hydrochloride
  • HY-D1622
    Cyanine3 DBCO hexafluorophosphate

    Cy3-DBCO hexafluorophosphate

    		 Fluorescent Dye Others
    Cyanine3 DBCO (Cy3-DBCO) hexafluorophosphate is a azide reactive probe, for imaging azide-labeled biomolecules via a copper-free "click-through" reaction.
    Cyanine3 DBCO hexafluorophosphate
  • HY-137124
    BB-F-Yne

    		Protein Arginine Deiminase Cancer
    BB-F-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of PAD1-4.are 2050, 1700, 1100, 3100 M -1min -1 respectively. BB-F-Yne can be used as a click probe to label PAD .
    BB-F-Yne
  • HY-137125
    BB-Cl-Yne

    		Protein Arginine Deiminase Cancer
    BB-Cl-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of PAD1-4.are 6400, 3600, 10800, 4900 M -1min -1 respectively. BB-Cl-Yne can be used as a click probe to label PAD .
    BB-Cl-Yne
  • HY-D2288
    CalFluor 580 azide

    		Fluorescent Dye Others
    CalFluor 580 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 580 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 580 azide
  • HY-D2289
    CalFluor 647 azide

    		Fluorescent Dye Others
    CalFluor 647 azide is a fluorogenic azide probe that is activated by Cu-catalyzed or metal-free click reaction. CalFluor 647 azide is not fluorescent until it is reacted with alkynes .
    CalFluor 647 azide
  • HY-D1625
    Cy5 DBCO chloride

    		Fluorescent Dye Others
    Cy5 DBCO chloride is an azide reaction probe and the addition of DBCO molecules allows the imaging of azide-labelled biomolecules by a copper-free “Click Chemistry” reaction . Cy5 DBCO (chloride) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Cy5 DBCO chloride
  • HY-151801
    DIBA-Cy5

    		mAChR Others
    DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the Kd value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart .
    DIBA-Cy5
  • HY-135639
    Alkyne-probe 1

    		Fluorescent Dye Others
    Alkyne-probe 1 is usually used as a Alkyne-labeled chemical or fluorescent probe. Alkyne-probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-probe 1
  • HY-W800705
    Tamra azide

    		Others Others
    Tamra azide is a red fluorescent probe. The azide group of Tamra azide can react with alkynes via copper-catalyzed click chemistry .
    Tamra azide
  • HY-135636
    Ponatinib Acid

    		Fluorescent Dye Others
    Ponatinib Acid, an analogue of Ponatinib, is usually used as a labeled chemical or fluorescent probe. Ponatinib Acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ponatinib Acid
  • HY-151644
    Fluorescein hydrazide

    		Fluorescent Dye Others
    Fluorescein hydrazide is a colorimetric probe formed by the reaction of dihydrazine adipate with fluorescein isothiocyanate. Fluorescein hydrazide can be used to label aldehyde and ketone groups .
    Fluorescein hydrazide
  • HY-D1478
    Fluorescent polyamine probe-1

    		Fluorescent Dye Others
    Fluorescent polyamine probe-1 (compound 15) is a linear polyamine probe with high uptake efficiency. Fluorescent polyamine probe-1 can be used for the research of transport system into cancer cells .
    Fluorescent polyamine probe-1
  • HY-151776
    Cy3 methyltetrazine

    TZ-Cy3

    		 Fluorescent Dye Others
    Cy3 methyltetrazine (TZ-Cy3) is a click chemistry reagent with methyltetrazine building blocks that is highly reactive towards cyclooctene. Cy3 methyltetrazine is also a tetrazine-modified fluorescent probe that can be used to analyze protein phosphorylation in solution and living cells .
    Cy3 methyltetrazine
  • HY-147097A
    EDA-DA TFA

    		Bacterial Infection
    EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
    EDA-DA TFA
  • HY-155772
    LUF7690

    		Adenosine Receptor Fluorescent Dye Inflammation/Immunology
    LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .
    LUF7690
  • HY-148864A
    (Z)-JQ1-TCO

    		Epigenetic Reader Domain Cancer
    JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo .
    (Z)-JQ1-TCO
  • HY-153748
    ML162-yne

    		Glutathione Peroxidase Cancer
    ML162-yne is a potent GPX4-inhibitor affinity probe . ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    ML162-yne
  • HY-151691
    Trisulfo-Cy3 Methyltetrazine

    		ADC Linker Others
    Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
    Trisulfo-Cy3 Methyltetrazine
  • HY-122743
    Iperoxo
    1 Publications Verification

    		 mAChR Neurological Disease
    Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR). [ 3H]Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors . Iperoxo is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Iperoxo
  • HY-159529
    DBCO-PEG4-Eosin 5-isothiocyanate

    		Fluorescent Dye Others
    DBCO-PEG4-Eosin 5-isothiocyanate is a fluorescent probe. DBCO-PEG4-Eosin 5-isothiocyanate contains a clickable functional group, DBCO, and four PEG units. DBCO-PEG4-Eosin 5-isothiocyanate can be used for various imaging detections .
    DBCO-PEG4-Eosin 5-isothiocyanate
  • HY-D1726
    8RK59

    		Deubiquitinase Cancer
    8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59 .
    8RK59
  • HY-110128
    Sulfidefluor 7-AM

    SF7-AM

    		 Fluorescent Dye Others
    Sulfidefluor 7-AM is a stable hydrogen sulphide (H2S) fluorescent probe . Sulfidefluor 7-AM is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Sulfidefluor 7-AM
  • HY-147097
    EDA-DA

    		Bacterial Infection
    EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    EDA-DA
  • HY-D1721
    Fluorescein-12-dATP

    		Fluorescent Dye Others
    Fluorescein-12-dATP is a fluorescent dye acting as the detection probe. Fluorescein-12-dATP can be used to label the thrombin-binding aptamers by catalytic polymerization of TdT (terminal deoxynucleotidyl transferase) . Fluorescein-12-dATP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Fluorescein-12-dATP
  • HY-154914
    GK16S

    		Deubiquitinase Others
    GK16S is a UCHL1 chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells . GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    GK16S
  • HY-151473
    PIKfyve-IN-1

    		PIKfyve Infection Cancer
    PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology . PIKfyve-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    PIKfyve-IN-1
  • HY-148864
    JQ1-TCO

    		Epigenetic Reader Domain Cancer
    JQ1-TCO is the double bond E configuration of JQ1-TCO (HY-148864A). JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo .
    JQ1-TCO
  • HY-151662
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid

    N3-TFBA

    		 ADC Linker Others
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid (N3-TFBA) is a click chemistry reagent containing an azide group. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid is a complex with FAM-labeled DNA probe. 4-Azido-2,3,5,6-tetrafluorobenzoic Acid can be used as versatile photoaffinity labeling agents to probe biological receptors. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    4-Azido-2,3,5,6-tetrafluorobenzoic Acid
  • HY-138995
    IMP-1710

    		Deubiquitinase Cancer
    IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells . IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    IMP-1710
  • HY-136205
    IA-Alkyne

    Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

    		 TRP Channel Infection Inflammation/Immunology
    IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    IA-Alkyne
  • HY-128676
    N-ε-propargyloxycarbonyl-L-lysine hydrochloride
    1 Publications Verification

    H-​L-​Lys(Poc)​-​OH hydrochloride

    		 Amino Acid Derivatives Cancer
    N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-ε-propargyloxycarbonyl-L-lysine hydrochloride
  • HY-139014
    N-ε-propargyloxycarbonyl-L-lysine
    1 Publications Verification

    H-​L-​Lys(Poc)​-​OH

    		 Fluorescent Dye Cancer
    N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-ε-propargyloxycarbonyl-L-lysine
  • HY-D1669
    Biotin-11-UTP

    		Fluorescent Dye Others
    Biotin-11-UTP is a Biotin-labeled uridine triphosphate (UTP), containing 11 atoms in the linker between biotin and UTP. Biotin-11-UTP can biotinylate transcribed RNA in vitro and has been widely used as labeling RNA probe . Biotin-11-UTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-11-UTP
  • HY-151708
    CalFluor 488 Azide

    		Fluorescent Dye Others
    CalFluor 488 Azide is a water-soluble fluorogenic azide probe. CalFluor 488 Azide is activated by Cu-catalyzed or metal-free click reaction. CalFluor 488 Azide is not fluorescent until it is reacted with alkynes . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    CalFluor 488 Azide
  • HY-D1725
    Cy3-dCTP

    		DNA Stain Cancer
    Cy3-dCTP is a DNA probe directly labeled by fluorescently labeled nucleotide. Cy3-dCTP also is cyanine-dye-labeled nucleotide triphosphate. Cy3-dCTP can be used for the research of imaging . Cy3-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cy3-dCTP
  • HY-D1506
    Fl-DIBO

    		Fluorescent Dye Others
    Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Fl-DIBO
  • HY-151679
    Fmoc-L-Lys(4-N3-Z)-OH

    		ADC Linker Others
    Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Lys(4-N3-Z)-OH acts as Lysine building-block for SPPS containing an Azide moiety as a bioorthogonal ligation handle, an infrared probe and a photo-affinity reagent. It can be decaged by trans-cyclooctenols via a strain-promoted 1,3-dipolar cycloaddition . Fmoc-L-Lys(4-N3-Z)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-L-Lys(4-N3-Z)-OH
  • HY-D1482
    Sulfo-Cy5-tetrazine

    		Fluorescent Dye Others
    Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Sulfo-Cy5-tetrazine
  • HY-D1583
    Cyanine5 DBCO
    1 Publications Verification

    DBCO-Cy5; Cyanine5 dibenzocyclooctyne

    		 Fluorescent Dye Others
    Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) .
    Cyanine5 DBCO
  • HY-152901
    Chol-N3

    		Fluorescent Dye Others
    Chol-N3 is a bioorthogonal-based chol probe. Chol-N3 can combine with super-resolution fluorescence microscopy (SRM), providing direct visualization of nanoscale lipid heterogeneity in the cell surface of resting living cells . Chol-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Chol-N3
  • HY-151744
    N3-TFBA-O2Oc

    		ADC Linker Others
    N3-TFBA-O2Oc is a click chemistry reagent containing an azide group and an aryl group. Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet et al. as versatile photoaffinity labeling agents to probe biological receptors. This type of compounds has been used as photo-cross linker (λmax=258 nm) in estrogen receptor studies and for direct surface coating of carbon and organic based polymers . N3-TFBA-O2Oc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-TFBA-O2Oc
  • HY-W127719
    Photobiotin acetate

    		Biochemical Assay Reagents Others
    Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Photobiotin acetate

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