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  4. N-ε-propargyloxycarbonyl-L-lysine hydrochloride

N-ε-propargyloxycarbonyl-L-lysine hydrochloride  (Synonyms: H-​L-​Lys(Poc)​-​OH hydrochloride)

Cat. No.: HY-128676 Purity: 98.34%
COA Handling Instructions

Molarity Calculator

N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals. N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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N-ε-propargyloxycarbonyl-L-lysine hydrochloride Chemical Structure

N-ε-propargyloxycarbonyl-L-lysine hydrochloride Chemical Structure

CAS No. : 1428330-91-9

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Based on 1 publication(s) in Google Scholar

Other Forms of N-ε-propargyloxycarbonyl-L-lysine hydrochloride:

N-ε-propargyloxycarbonyl-L-lysine hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-ε-propargyloxycarbonyl-L-lysine hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals[1][2]. N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Labeling of N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride-carrying cellular proteins, such as Sec61β, Htt74Q and the histone H3 variant H3.3, with a sensitive Raman tag by click chemistry for molecular hyperspectral SRS imaging[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-ε-propargyloxycarbonyl-L-lysine hydrochloride Related Antibodies
Molecular Weight

264.71

Formula

C10H17ClN2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C#CCOC(NCCCC[C@H](N)C(O)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (377.77 mM)

DMSO : 100 mg/mL (377.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7777 mL 18.8886 mL 37.7772 mL
5 mM 0.7555 mL 3.7777 mL 7.5554 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (9.44 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (9.44 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.34%

COA (245 KB) HNMR (140 KB) LCMS (131 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.7777 mL 18.8886 mL 37.7772 mL 94.4430 mL
5 mM 0.7555 mL 3.7777 mL 7.5554 mL 18.8886 mL
10 mM 0.3778 mL 1.8889 mL 3.7777 mL 9.4443 mL
15 mM 0.2518 mL 1.2592 mL 2.5185 mL 6.2962 mL
20 mM 0.1889 mL 0.9444 mL 1.8889 mL 4.7221 mL
25 mM 0.1511 mL 0.7555 mL 1.5111 mL 3.7777 mL
30 mM 0.1259 mL 0.6296 mL 1.2592 mL 3.1481 mL
40 mM 0.0944 mL 0.4722 mL 0.9444 mL 2.3611 mL
50 mM 0.0756 mL 0.3778 mL 0.7555 mL 1.8889 mL
60 mM 0.0630 mL 0.3148 mL 0.6296 mL 1.5740 mL
80 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1805 mL
100 mM 0.0378 mL 0.1889 mL 0.3778 mL 0.9444 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-ε-propargyloxycarbonyl-L-lysine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-ε-propargyloxycarbonyl-L-lysine1428330-91-9H-​L-​Lys(Poc)​-​OHAmino Acid DerivativesInhibitorinhibitorinhibit

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