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DDC-01-163

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139997
    DDC-01-163

    		PROTACs EGFR Cancer
    DDC-01-163 is a mutant-selective allosteric PROTAC-based EGFR degrader, with an IC50 of 45 nM (Pink: EGFR ligand (HY-151048); Black: linker (HY-W008005); Blue: CRBN ligand (HY-14658)) .
    DDC-01-163
  • HY-170351
    NH2-PEG2-OMs

    		PROTAC Linkers Cancer
    NH2-PEG2-OMs is the linker, that could be used for synthesis of PROTAC degrader DDC-01-163 (HY-139997) .
    NH2-PEG2-OMs
  • HY-170350
    Pomalidomide-PEG2-OMs

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-PEG2-Oms (CRBN ligand Pomalidomide (HY-10984)) is an E3 Ligase Ligand-Linker Conjugate for EGFR PROTAC DDC-01-163 (HY-139997) .
    Pomalidomide-PEG2-OMs
  • HY-151048
    JBJ-07-149

    		EGFR Cancer
    JBJ-07-149 is an inhibitor for EGFRL858R/T790M with an IC50 of 1.1 nM. JBJ-07-149 inhibits the proliferation of cell Ba/F3 with IC50 of 4.9 μM and 0.148 μM, without and with presence of Cetuximab (HY-P9905). JBJ-07-149 can be used as ligand for target protein in synthesis of DDC-01-163 (HY-139997) .
    JBJ-07-149

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