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DHEA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (3) Apoptosis (1) Cannabinoid Receptor (1) Cytochrome P450 (2) Endogenous Metabolite (12) GABA Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (1) Reactive Oxygen Species (1) Steroid Sulfatase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (6) Inflammation/Immunology (1) Metabolic Disease (7) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14650

*DHEA* Maximum Cited Publications 26 Publications Verification Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Androgen Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-113416

Dehydroepiandrosterone sulfate 5 Publications Verification DHEA sulfate; Prasterone sulfate	Endogenous Metabolite	Neurological Disease
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-B1405

Dehydroisoandrosterone 3-acetate 1 Publications Verification Dehydroepiandrosterone 3-acetate; DHEA acetate	Androgen Receptor	Endocrinology Cancer
Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.

HY-113031S

16α-Hydroxydehydroepiandrosterone-d6 16α-hydroxy-DHEA-d₆; 16α-OH-DHEA-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Others
16α-Hydroxydehydroepiandrosterone-d₆ (16α-Hydroxy-DHEA-d₆) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone[1].

HY-113031S1

16α-Hydroxydehydroepiandrosterone-d5 16α-Hydroxy-DHEA-d₅; 16α-OH-DHEA-d₅	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
16α-Hydroxydehydroepiandrosterone-d₅ (16α-Hydroxy-DHEA-d₅) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone (HY-113031) .

HY-14650R

DHEA (Standard) Prasterone (Standard); Dehydroisoandrosterone (Standard); Dehydroepiandrosterone (Standard)	Androgen Receptor Endogenous Metabolite	Metabolic Disease
DHEA (Prasterone) (Standard) is the analytical standard of DHEA. This product is intended for research and analytical applications. DHEA is a steroid hormone .

HY-N9483

7-Keto-DHEA 7-Oxo-DHEA; 7-Ketodehydroepiandrosterone; 7-Oxodehydroepiandrosterone	GABA Receptor	Metabolic Disease
7-Keto-DHEA binds to GABA Receptor, and reduces the ethanol intake in rats. 7-Keto-DHEA exhibits potential in investigation of alcohol dependence disorders .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Cytochrome P450 Mitochondrial Metabolism	Metabolic Disease Cancer
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

HY-113031

16a-Hydroxydehydroisoandrosterone 16α-Hydroxy-DHEA; 16α-OH-DHEA; 16α-hydroxy DHEA	Cytochrome P450	Endocrinology
16a-Hydroxydehydroisoandrosterone (16α-Hydroxy-DHEA) is a metabolite of the endogenous steroid hormone dehydroepiandrosterone. 16α-hydroxy Dehydroepiandrosterone is formed from dehydroepiandrosterone via 16-hydroxylation by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in adult human liver microsomes, as well as by fetal recombinant CYP3A7. It is a precursor to fetal estrogens, including estriol.

HY-138970

(±)19(20)-EDP ethanolamide 19,20-DHEA epoxide; 19,20-Epoxy docosapentaenoic acid ethanolamide; 19,20-EDP-EA	Interleukin Related	Others
(±)19(20)-EDP ethanolamide (19,20-DHEA epoxide) (compound 19) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.

HY-100197

Synaptamide 1 Publications Verification N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide	Cannabinoid Receptor	Neurological Disease
Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. Synaptamide binds to both the cannabinoid-1 and 2 (CB1 and CB2) cannabinoid receptors and has anti-inflammatory properties. Synaptamide is the first small-molecule endogenous ligand of an adhesion G protein-coupled receptor (aGPCR) .

HY-139247

pNPS-DHA	Others	Inflammation/Immunology
pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC₅₀ of 15 μM .

HY-138107

Arimistane	Endogenous Metabolite	Metabolic Disease
Arimistane is a metabolite of 7-oxo-DHEA and can be used as a diagnostic marker of 7-oxo-DHEA administration .Arimistane is a metabolite of 7-oxo-DHEA and can be used as a diagnostic marker of 7-oxo-DHEA administration .

HY-116377

DU-14	Steroid Sulfatase	Neurological Disease
DU-14 is a potent steroid sulfatase inhibitor with an IC₅₀ of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC₅₀ = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity .

HY-113416R

Dehydroepiandrosterone sulfate (Standard)	Endogenous Metabolite	Neurological Disease
Dehydroepiandrosterone sulfate (Standard) is the analytical standard of Dehydroepiandrosterone sulfate. This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-B0765

Dehydroepiandrosterone sulfate sodium salt 5 Publications Verification Sodium prasterone sulfate	Endogenous Metabolite	Metabolic Disease
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone .

HY-B0765R

Dehydroepiandrosterone sulfate (sodium salt) (Standard) Sodium prasterone sulfate (Standard)	Endogenous Metabolite	Metabolic Disease
Dehydroepiandrosterone sulfate (sodium salt) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (sodium salt). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone .

HY-113263

17a-Hydroxypregnenolone 1 Publications Verification	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-113263S

17a-Hydroxypregnenolone-d3	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone-d₃ is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-113263R

17a-Hydroxypregnenolone (Standard)	Endogenous Metabolite	Endocrinology
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-161340

Anti-melanoma agent 2	Apoptosis	Cancer
Anti-melanoma agent 2 (Compound IId) is a steroid hybrid that effectively induces endoplasmic reticulum stress (ERS) and causes apoptosis. Anti-melanoma agent 2 shows anti-melanoma effects .

HY-134545

N-Arachidonoyl-L-alanine NALA	Reactive Oxygen Species	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

Cat. No.	Product Name	Target	Research Area

HY-134545

N-Arachidonoyl-L-alanine NALA	Reactive Oxygen Species	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14650

*DHEA* Maximum Cited Publications 26 Publications Verification Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Androgen Receptor Endogenous Metabolite
DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

HY-113416

Dehydroepiandrosterone sulfate 5 Publications Verification DHEA sulfate; Prasterone sulfate	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-B1405

Dehydroisoandrosterone 3-acetate 1 Publications Verification Dehydroepiandrosterone 3-acetate; DHEA acetate	Classification of Application Fields Disease Research Fields Cancer	Androgen Receptor
Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.

HY-113416R

Dehydroepiandrosterone sulfate (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Dehydroepiandrosterone sulfate (Standard) is the analytical standard of Dehydroepiandrosterone sulfate. This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses .

HY-B0765

Dehydroepiandrosterone sulfate sodium salt 5 Publications Verification Sodium prasterone sulfate	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone .

HY-113263

17a-Hydroxypregnenolone 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

HY-14650R

DHEA (Standard) Prasterone (Standard); Dehydroisoandrosterone (Standard); Dehydroepiandrosterone (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Androgen Receptor Endogenous Metabolite
DHEA (Prasterone) (Standard) is the analytical standard of DHEA. This product is intended for research and analytical applications. DHEA is a steroid hormone .

HY-N9483

7-Keto-DHEA 7-Oxo-DHEA; 7-Ketodehydroepiandrosterone; 7-Oxodehydroepiandrosterone	Structural Classification Source classification Endogenous metabolite Steroids	GABA Receptor
7-Keto-DHEA binds to GABA Receptor, and reduces the ethanol intake in rats. 7-Keto-DHEA exhibits potential in investigation of alcohol dependence disorders .

HY-145751

7α-Hydroxy-DHEA 7α-Hydroxydehydroepiandrosterone; 3β,7α-Dihydroxy-Δ5-androsten-17-one	Structural Classification Source classification Endogenous metabolite Steroids	Cytochrome P450 Mitochondrial Metabolism
7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA (HY-14650), catalyzed by intracellular steroid 7α-hydroxylases such as P450 2A1. 7α-Hydroxy-DHEA exhibits biological activity comparable to DHEA but does not convert into compounds with androgenic or estrogenic activity. It induces the activity of thermogenic enzymes such as mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, enhancing heat production and reducing food utilization efficiency. As a more efficient and safer metabolite compared to DHEA, 7α-Hydroxy-DHEA holds potential for studies in the fields of obesity, metabolic diseases, and adrenal carcinoma .

HY-B0765R

Dehydroepiandrosterone sulfate (sodium salt) (Standard) Sodium prasterone sulfate (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
Dehydroepiandrosterone sulfate (sodium salt) (Standard) is the analytical standard of Dehydroepiandrosterone sulfate (sodium salt). This product is intended for research and analytical applications. Dehydroepiandrosterone sulfate sodium salt (DHEAS) is the most abundant circulating steroid in human. Dehydroepiandrosterone sulfate sodium salt (DHEAS) affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone .

HY-113263R

17a-Hydroxypregnenolone (Standard)	Structural Classification Immune System Disorder Classification of Application Fields Source classification Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

Cat. No.	Compare	Product Name	Species	Source

HY-P71343

	SULT2A1 Protein, Human (His) Bile Salt Sulfotransferase; Dehydroepiandrosterone Sulfotransferase; DHEA-ST; Hydroxysteroid Sulfotransferase; HST; ST2; ST2A3; Sulfotransferase 2A1; ST2A1; SULT2A1; HST; STD	Human	E. coli
	The SULT2A1 protein utilizes PAPS for critical sulfonation of steroids and bile acids in the liver and adrenal glands. Its multifunctional activity extends to a variety of compounds, enhancing its water solubility to facilitate renal excretion. SULT2A1 Protein, Human (His) is the recombinant human-derived SULT2A1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SULT2A1 Protein, Human (His) is 284 a.a., with molecular weight of 34-38 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-113031S

16α-Hydroxydehydroepiandrosterone-d6
16α-Hydroxydehydroepiandrosterone-d₆ (16α-Hydroxy-DHEA-d₆) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone[1].

HY-113031S1

16α-Hydroxydehydroepiandrosterone-d5
16α-Hydroxydehydroepiandrosterone-d₅ (16α-Hydroxy-DHEA-d₅) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone (HY-113031) .

HY-113263S

17a-Hydroxypregnenolone-d3
17a-Hydroxypregnenolone-d₃ is the deuterium labeled 17a-Hydroxypregnenolone. 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83674

	*Dehydroepiandrosterone/DHEA* Antibody** DHEA,androstenolone,dehydroisoandrosterone,prasterone,diandrone,psicosterone,trans-dehydroandrosterone, diandron,17-hormoforin	ELISA	Species independent

HY-P82116

	Sulfotransferase 2A1 Antibody (YA1861) HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Sulfotransferase 2A1 Antibody (YA1861) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1861), targeting Sulfotransferase 2A1, with a predicted molecular weight of 34 kDa (observed band size: 34 kDa). Sulfotransferase 2A1 Antibody (YA1861) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

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DHEA

Inhibitors & Agonists

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