1. Metabolic Enzyme/Protease
  2. Steroid Sulfatase
  3. DU-14

DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity.

For research use only. We do not sell to patients.

DU-14 Chemical Structure

DU-14 Chemical Structure

CAS No. : 186303-55-9

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Based on 1 publication(s) in Google Scholar

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Description

DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].

In Vitro

DU-14 (0.001-10 μM, 18 h) inhibits estrone sulfatase activity in MDA-MB-23l cell, with an IC50 of 350 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DU-14 (30 mg/kg, i.p., once time) inhibits steroid sulfatase activity in both brain and liver tissues and enhances the memory-enhancing properties of DHEAS in rats with scopolamine-induced amnesia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

426.61

Formula

C22H38N2O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCC(NCCC1=CC=C(C=C1)OS(N)(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (293.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3441 mL 11.7203 mL 23.4406 mL
5 mM 0.4688 mL 2.3441 mL 4.6881 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3441 mL 11.7203 mL 23.4406 mL 58.6015 mL
5 mM 0.4688 mL 2.3441 mL 4.6881 mL 11.7203 mL
10 mM 0.2344 mL 1.1720 mL 2.3441 mL 5.8602 mL
15 mM 0.1563 mL 0.7814 mL 1.5627 mL 3.9068 mL
20 mM 0.1172 mL 0.5860 mL 1.1720 mL 2.9301 mL
25 mM 0.0938 mL 0.4688 mL 0.9376 mL 2.3441 mL
30 mM 0.0781 mL 0.3907 mL 0.7814 mL 1.9534 mL
40 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4650 mL
50 mM 0.0469 mL 0.2344 mL 0.4688 mL 1.1720 mL
60 mM 0.0391 mL 0.1953 mL 0.3907 mL 0.9767 mL
80 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7325 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.5860 mL
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Product Name:
DU-14
Cat. No.:
HY-116377
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