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Results for "

DHPS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Antibiotic (4) Apoptosis (1) Bacterial (5) Calcium Channel (9) Chloride Channel (1) DNA/RNA Synthesis (6) Endogenous Metabolite (1) Isotope-Labeled Compounds (2) Necroptosis (1) RIP kinase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (7) Infection (6) Inflammation/Immunology (3) Neurological Disease (3)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115712

DHPS-IN-1	DNA/RNA Synthesis	Cancer
DHPS-IN-1, with the best *DHPS* inhibitory potency (IC₅₀ = 0.014 μM), exhibits excellent inhibition against melanoma cells.

HY-108314A

GC7 Sulfate 3 Publications Verification	DNA/RNA Synthesis	Cancer
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

HY-135218A

AV-153 free base 1 Publications Verification	DNA/RNA Synthesis	Cancer
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity .

HY-RS03737

DHPS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DHPS Human Pre-designed siRNA Set A contains three designed siRNAs for DHPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DHPS Human Pre-designed siRNA Set A DHPS Human Pre-designed siRNA Set A

HY-106832

Vatanidipine Watanidipine; AE0047 free base	Calcium Channel	Cardiovascular Disease Neurological Disease
Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings .

HY-106766

DHP-218	Calcium Channel	Cardiovascular Disease
DHP-218 is a vasodilatory calcium antagonist with pronounced and long-lasting antihypertensive effects .

HY-108314

GC-7	DNA/RNA Synthesis	Cancer
GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.

HY-161027

DHP-B	Apoptosis	Cancer
DHP-B possesses anti-cancer activity and induces apoptosis. DHP-B covalently binds to Cys96 of CPT1A, blocks FAO, and disrupts the mitochondrial CPT1A-VDAC1 interaction, leading to increased mitochondrial permeability and reduced oxygen consumption and energy metabolism in CRC cells. DHP-B can be isolated from the plant Peperomia dindygulensis .

HY-126171

Hypusine	Endogenous Metabolite	Others
Hypusine is a natural amino acid. The post-translational synthesis of hypusine is mainly catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) .

HY-135218

AV-153	DNA/RNA Synthesis	Cancer
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 has anti-cancer activity .

HY-120411

Sadopine	Calcium Channel	Others
Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels .

HY-106832A

Vatanidipine hydrochloride Watanidipine hydrochloride; AE0047	Calcium Channel	Cardiovascular Disease Neurological Disease
Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings .

HY-B0212

Sulfapyridine	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC₅₀ of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-B0612DS1

Lercanidipine-d3 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-I0447A

Sodium 4-aminosalicylate dihydrate 1 Publications Verification 4-Aminosalicylic acid sodium salt dihydrate	Bacterial Antibiotic	Infection
Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase (DHFR) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity .

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride	Calcium Channel	Cardiovascular Disease
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

HY-106927

Bay Y5959	Calcium Channel	Cardiovascular Disease
Bay Y5959 is a potent calcium channel agonist. Bay Y5959 binds to the DHP receptor in a voltage-dependent manner increases both the mean open time and the mean closed time of the Ca-channel. Bay Y5959 has the potential for the research of congestive heart failure, arrhythmic .

HY-155804

RIP1 kinase inhibitor 8	Necroptosis RIP kinase	Inflammation/Immunology
RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC₅₀ of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species .

HY-147721

Dihydropteroate synthase-IN-1	Bacterial	Infection
Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .

HY-B0212R

Sulfapyridine (Standard)	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC₅₀ of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-117090

(rac)-AL-37350A (rac)-4,5-DHP-AMT	5-HT Receptor	Others
(rac)-AL-37350A ((rac)-4,5-DHP-AMT) is a 5-HT2 receptor agonist with intraocular pressure-lowering activity. (rac)-AL-37350A has high affinity and selectivity for the 5-HT2 receptor and effectively reduces intraocular pressure in conscious hypertensive cynomolgus monkeys.

HY-106808

Cerebrocrast IOS-1.1212	Calcium Channel Chloride Channel	Neurological Disease
Cerebrocrast (IOS-1.1212) is a 1,4-dihydropyridine (DHP) derivative. Cerebrocrast has a high affinity for the membrane lipid bilayer and it can easily penetrate the blood-brain barrier and incorporate into the plasma and organelle membranes, including those of mitochondria. Cerebrocrast promotes the cotransport of H+ and Cl- in rat liver mitochondria. Cerebrocrast also exhibits neuroprotective and cognition enhancer properties .

HY-I0447AR

Sodium 4-aminosalicylate (dihydrate) (Standard)	Bacterial Antibiotic	Infection
Sodium 4-aminosalicylate (dihydrate) (Standard) is the analytical standard of Sodium 4-aminosalicylate (dihydrate). This product is intended for research and analytical applications. Sodium 4-aminosalicylate (Sodium para-Aminosalicylic acid) dihydrate is para-aminosalicylic acid (PAS), a dihydrofolate reductase (DHFR) inhibitor and antituberculous agent. PAS is incorporated into the folate pathway via dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate the hydroxydihydrofolate antimetabolite, which in turn inhibits DHFR enzyme activity .

HY-172109

DNA Gyrase-IN-15	DNA/RNA Synthesis	Infection
DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of *DHPS* and DNA gyrase, with IC₅₀s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis .

Cat. No.	Compare	Product Name	Species	Source

HY-P70038

	Deoxyhypusine synthase/DHS Protein, Human (His) 1 Publications Verification rHuDeoxyhypusine synthase/DHS, His; Deoxyhypusine Synthase; DHS; DHPS; DS	Human	E. coli
	The deoxyhorseuridine synthase (DHS) protein plays a crucial role in the NAD-dependent oxidative cleavage of spermidine, followed by the transfer of the butylamine moiety of spermidine to the ε-amino group of the eIF-5A precursor protein. On the key lysine. Deoxyhypusine synthase/DHS Protein, Human (His) is the recombinant human-derived Deoxyhypusine synthase/DHS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Deoxyhypusine synthase/DHS Protein, Human (His) is 369 a.a., with molecular weight of ~44.52 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-B0612DS1

Lercanidipine-d3 hydrochloride
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS1

Lercanidipine-13C,d3-1 hydrochloride
Lercanidipine- ¹³C,d₃-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[1][2][3].

HY-B0612AS

Lercanidipine-13C,d3 hydrochloride
Lercanidipine- ¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Lercanidipine hydrochloride[1]. Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect[2][3][4].

DHPS Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
DHPS Human Pre-designed siRNA Set A contains three designed siRNAs for DHPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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