Vatanidipine hydrochloride  (Synonyms: Watanidipine hydrochloride; AE0047)

Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings^[1][2].

Vatanidipine (1-10 mg/kg, p.o.) suppresses the systolic blood pressure of spontaneously hypertensive rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

759.72

C₄₁H₄₄Cl₂N₄O₆

133743-71-2

O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC([N+]([O-])=O)=CC=C2)OCCC3=CC=C(N4CCN(C(C5=CC=CC=C5)C6=CC=CC=C6)CC4)C=C3.Cl.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Matsumura Y, et al. Vatanidipine hydrochloride: a new long-lasting antihypertensive agent. Expert Opin Investig Drugs. 2001 Jan;10(1):139-55.  [Content Brief]

  [2]. H Shinyama, et al. Effects of the calcium antagonist AE0047 on the development of neurological deficit and infarction after middle cerebral artery occlusion in stroke-prone spontaneously hypertensive rats. J Pharm Pharmacol. 1997 Sep;49(9):919-24.  [Content Brief]