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Results for "

Diphyllin

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2532
    Diphyllin

    		VSV HIV Proton Pump Influenza Virus Infection Inflammation/Immunology Cancer
    Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus . Diphyllin is a vacuolar type H +-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts . Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities .
    Diphyllin
  • HY-N9351
    Cleistanthin B

    Diphyllin O-glucoside

    		 SARS-CoV Infection Cardiovascular Disease Metabolic Disease Cancer
    Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 µM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo .
    Cleistanthin B
  • HY-161691
    EBOV-IN-9

    		Filovirus Infection
    EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC50 of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC50 of 107 nM .
    EBOV-IN-9

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