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Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

E1 activating enzyme

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (3) Apoptosis (1) Calcium Channel (1) Microtubule/Tubulin (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1)

Inhibitors & Agonists

Screening Libraries

Recombinant Proteins

Antibodies

Targets Recommended: NEDD8-activating Enzyme E1/E2/E3 Enzyme Angiotensin-converting Enzyme (ACE) FLAP Platelet-activating Factor Receptor (PAFR) ATF6 IRE1 PACAP Receptor TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114304

COH000 1 Publications Verification	E1/E2/E3 Enzyme	Cancer
COH000 is an allosteric, covalent and irreversible inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC₅₀ of 0.2 μM for SUMOylation in vitro .

HY-13296

PYR-41 10+ Cited Publications	E1/E2/E3 Enzyme Apoptosis	Cancer
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

HY-110273

N106	Calcium Channel E1/E2/E3 Enzyme	Cardiovascular Disease
N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research .

HY-163105

Tubulin/NEDDylation-IN-1	Microtubule/Tubulin	Cancer
Tubulin/NEDDylation-IN-1 (compound C11) is a dual inhibitor of tubulin (Microtubule/Tubulin)-NEDDylation (IC₅₀ for tubulin=2.40 μM), which has strong anti-proliferative activity. Neddylation is a protein post-translational modification that covalently tags the ubiquitin-like protein NEDD8 to target proteins. Tubulin/NEDDylation-IN-1 forms hydrogen bonds with residues of tubulin and E1 NEDD8 activating enzyme (NAE) through methoxy and dithiocarbamate groups and inhibits NEDDylation and microtubulin in an ATP-dependent manner. tube polymerization .

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library	269 compounds
Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc. MCE offers a unique collection of 269 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Ubiquitination Compound Library

269 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 269 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

Species:	Human (3)
Tag:	His (3) Strep (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71395

	UBA5 Protein, Human (His) Ubiquitin-like modifier-activating enzyme 5; ThiFP1; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1; UBE1DC1; UBA5	Human	E. coli
	The UBA5 protein activates UFM1 in ufmylation, linking the C-terminal glycine residue of UFM1 to a cysteine residue in E1. UBA5 Protein, Human (His) is the recombinant human-derived UBA5 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701353

	UBE1L2/UBA6 Protein, Human (Sf9, His, Strep) UBA6; Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme 6; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2	Human	Sf9 insect cells
	The ubiquitin E1 enzyme initiates ubiquitination by adenylating ubiquitin with ATP and forming a thioester bond with the E1 enzyme. It exhibits specificity for ubiquitin and excludes ubiquitin-like peptides. UBE1L2/UBA6 Protein, Human (Sf9, His, Strep) is the recombinant human-derived UBE1L2/UBA6 protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of UBE1L2/UBA6 Protein, Human (Sf9, His, Strep) is 1051 a.a., .

HY-P79454

	ISG15 E1/UBE1L Protein, Human (sf9, His, Strep) Ubiquitin-like modifier-activating enzyme 7; UBA7; Ubiquitin-activating enzyme 7; D8; Ubiquitin-activating enzyme E1 homolog; UBE1L; UBE2	Human	Sf9 insect cells
	The ISG15 E1/UBE1L protein initiates ubiquitination by adenylating the C-terminal glycine of ubiquitin with ATP to form a thioester bond with its cysteine residue. This produces ubiquitin-E1 thioester and free AMP. ISG15 E1/UBE1L Protein, Human (sf9, His, Strep) is the recombinant human-derived ISG15 E1/UBE1L protein, expressed by Sf9 insect cells , with N-8*His, N-Strep labeled tag. The total length of ISG15 E1/UBE1L Protein, Human (sf9, His, Strep) is 1011 a.a., .

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HY-P80559

	ATG7 Antibody hAGP7; Ubiquitin-activating enzyme E1-like protein; APG7L	WB	Human, Mouse, Rat
	ATG7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to ATG7. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P82072

	*E1 Ubiquitin Activating* Enzyme Antibody (YA1817)** UBA1; A1S9T; UBE1; Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; Ubiquitin-activating enzyme E1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	E1 Ubiquitin Activating Enzyme Antibody (YA1817) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1817), targeting E1 Ubiquitin Activating Enzyme, with a predicted molecular weight of 118 kDa (observed band size: 118 kDa). E1 Ubiquitin Activating Enzyme Antibody (YA1817) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P82386

	APPBP1 Antibody (YA2131) NEDD8 activating enzyme E1 subunit 1; HPP1; ula-1; APPBP1; A-116A10.1	WB, IP	Human
	APPBP1 Antibody (YA2131) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2131), targeting APPBP1, with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). APPBP1 Antibody (YA2131) can be used for WB, IP experiment in human background.

HY-P82102

	SAE1 Antibody (YA1847) SAE1; AOS1; SUA1; UBLE1A; SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A	WB, ICC/IF, IP, FC	Human, Rat
	SAE1 Antibody (YA1847) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1847), targeting SAE1, with a predicted molecular weight of 38 kDa (observed band size: 38 kDa). SAE1 Antibody (YA1847) can be used for WB, ICC/IF, IP, FC experiment in human, rat background.

HY-P83551

	*NEDD8 Activating* Enzyme E1C Antibody (YA3296)** NAE2; UBE1C; hUBA3	WB	Human, Mouse
	NEDD8 Activating Enzyme E1C Antibody (YA3296) is a biotin-conjugated non-conjugated IgG antibody, targeting NEDD8 Activating Enzyme E1C, with a predicted molecular weight of 52 kDa (observed band size: 52 kDa). NEDD8 Activating Enzyme E1C Antibody (YA3296) can be used for WB experiment in human, mouse background.

HY-P82584

	UBA2 Antibody (YA2329) UBA2; SAE2; UBLE1B; HRIHFB2115; SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B	WB, ICC/IF, IP	Human, Rat
	UBA2 Antibody (YA2329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2329), targeting UBA2, with a predicted molecular weight of 71 kDa (observed band size: 90 kDa). UBA2 Antibody (YA2329) can be used for WB, ICC/IF, IP experiment in human, rat background.

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