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Electron microscopy

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (3) Biochemical Assay Reagents (4) Calcium Channel (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Tau Protein (1) Thymidylate Synthase (1) Tyrosinase (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103311

Ruthenium red 5+ Cited Publications Ammoniated ruthenium oxychloride	Calcium Channel	Cardiovascular Disease
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker .

HY-W040201

CHAPSO 3-[3-(Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate	Biochemical Assay Reagents	Others
CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy .

HY-137179

Glyco-diosgenin	Biochemical Assay Reagents	Others
Glyco-diosgenin is a synthetic surfactant and detergent for extracting proteins from membranes for structure and function studies, and single-particle cryo-electron microscopy (cryoEM) studies of membrane proteins .

HY-B2192A

Diastase, Aspergillus oryzae Maltin	Biochemical Assay Reagents	Others
Diastase is an amylase from Aspergillus oryzae that hydrolyzes starch into sugars .

HY-149764

Aβ42 agonist-2	Amyloid-β	Neurological Disease
Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-149763

Aβ42 agonist-1	Amyloid-β	Neurological Disease
Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .

HY-122297

H-Arg-Phe-OH	Endogenous Metabolite	Others
H-Arg-Phe-OH is an amphipathic peptide. H-Arg-Phe-OH has the ability to induce native-like protein aggregation. H-Arg-Phe-OH can induce aggregation of the neutral model protein yeast alcohol dehydrogenase (ADH) .

HY-111137

Puquitinib XC-302 free base	Akt	Cancer
Puquitinib (XC-302 free base) is a multi-target inhibitor with the activity of inducing autophagy in nasopharyngeal carcinoma cells by inhibiting the PI3K/AKT/mTOR signaling pathway. Puquitinib was able to inhibit the proliferation of CNE-2 cells, showing a dose-dependent antiproliferative effect. Puquitinib induced the formation of autophagosomes and autolysosomes in CNE-2 cells, which were observed by fluorescence microscopy and electron microscopy. Puquitinib promoted the formation of LC3-II and increased the expression of beclin 1, while reducing the level of p62. Puquitinib inhibited the PI3K/AKT/mTOR pathway by reducing the expression of p-AKT and p-mTOR. Puquitinib also induced apoptosis in CNE-2 cells, and when autophagy was inhibited, the apoptosis rate was reduced, which means that autophagy may interact with apoptosis to induce cell death .

HY-W250179

Hexaethylene glycol monohexadecyl ether Polyoxyethylene (6) cetyl ether	Biochemical Assay Reagents	Others
Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

HY-169197

D-688	Tau Protein Amyloid-β	Neurological Disease
D-688 is an inhibitor of Tau and Aβ. D-688 can reverse Aβ1–42-induced toxicity in SH-SH5Y cells and has significant neuroprotective properties. D-688 can improve the survival rate of Drosophila melanogaster expressing the human tau protein isoform (2N4R) .

HY-W129441

N-Acetyl-4-S-cysteaminylphenol N-Ac-4-S-CAP	DNA/RNA Synthesis Tyrosinase Thymidylate Synthase	Others
N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.

Cat. No.	Product Name	Type

HY-103311

Ruthenium red 5+ Cited Publications Ammoniated ruthenium oxychloride	Dyes
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker .

Cat. No.	Product Name	Type

HY-W040201

CHAPSO 3-[3-(Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate	Surfactants
CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy .

CHAPSO

3-[3-(Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate

Surfactants

CHAPSO is a zwitterionic detergent that is thermally stable. CHAPSO is able to broaden the particle orientation distribution, enabling single-particle cryo-electron microscopy (cryo-EM) to produce isotropically uniform maps. CHAPSO can eliminate the directional bias of bacterial transcription complexes and help determine the structure of bacterial transcription complexes under cryo-electron microscopy .

HY-W250179

Hexaethylene glycol monohexadecyl ether Polyoxyethylene (6) cetyl ether	Biochemical Assay Reagents
Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

Hexaethylene glycol monohexadecyl ether

Polyoxyethylene (6) cetyl ether

Biochemical Assay Reagents

Hexaethylene glycol monohexadecyl ether, is a nonionic surfactant belonging to the polyethylene glycol (PEG) ether family. It has a hydrophilic head and a lipophilic tail, which makes it suitable for a wide range of applications. Specifically, Hexaethylene glycol monohexadecyl ether is commonly used in membrane protein research, for solubilization and stabilization of proteins, and for structural analysis techniques such as X-ray crystallography and electron microscopy. Additionally, Hexaethylene glycol monohexadecyl ether is used in a variety of other industrial and research applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Its unique properties make it ideal for facilitating interactions between molecules with different physicochemical properties.

Cat. No.	Product Name	Target	Research Area

HY-122297

H-Arg-Phe-OH	Endogenous Metabolite	Others
H-Arg-Phe-OH is an amphipathic peptide. H-Arg-Phe-OH has the ability to induce native-like protein aggregation. H-Arg-Phe-OH can induce aggregation of the neutral model protein yeast alcohol dehydrogenase (ADH) .

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