Eya

By Targets:	Drug Metabolite (1) Hedgehog (1) Phosphatase (5) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (4) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

NCGC00249987	Phosphatase	Cancer
NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of *Eya2* inhibitor with IC₅₀s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells .

DS-1-38	Hedgehog	Cancer
DS-1-38 is an *EYA1* antagonist that blocks Sonic Hedgehog (SHH) signaling. EYA1 is a haloacid dehalogenase phosphatase and transcription factor that regulates tumorigenesis and proliferation in SHH medulloblastoma (SHH-MB) .

MLS000544460	Phosphatase	Cancer
MLS000544460 is a highly selective and reversible Eya2 phosphatase inhibitor with a K_d of 2.0 μM and an IC₅₀ of 4 μM. MLS000544460 inhibit Eya2 phosphatase mediated cell migration and has anti-cancer activity .

NCGC00378430 1 Publications Verification	Phosphatase	Cancer
NCGC00378430 is a potent *SIX1/EYA2* interaction inhibitor. NCGC00378430 partially reverses transcriptional and metabolic profiles mediated by SIX1 overexpression and reverses SIX1-induced TGF-β signaling and epithelial-mesenchymal transition (EMT). NCGC00378430 inhibits SIX1-mediated breast cancer metastasis in a mouse model .

6-Hydroxybenzbromarone	Drug Metabolite Phosphatase	Cardiovascular Disease
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC₅₀ value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting .

EYA2-IN-1	Phosphatase	Cancer
EYA2-IN-1(compound 2e) is a novel allosteric EYA2 inhibitor. EYA2-IN-1 has anti-tumor activity .

EYA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EYA1 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA1 Human Pre-designed siRNA Set A EYA1 Human Pre-designed siRNA Set A

EYA4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EYA4 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA4 Human Pre-designed siRNA Set A EYA4 Human Pre-designed siRNA Set A

EYA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EYA3 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA3 Human Pre-designed siRNA Set A EYA3 Human Pre-designed siRNA Set A

EYA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EYA2 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA2 Human Pre-designed siRNA Set A EYA2 Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Application	Reactivity

	EYA2 Antibody (YA2905) EAB1	WB, IP	Human
	EYA2 Antibody (YA2905) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2905), targeting EYA2, with a predicted molecular weight of 59 kDa (observed band size: 59 kDa). EYA2 Antibody (YA2905) can be used for WB, IP experiment in human background.

Compare Products

Cat. No.	Product Name		Classification

EYA1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EYA1 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EYA4 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EYA3 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EYA2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EYA2 Human Pre-designed siRNA Set A contains three designed siRNAs for EYA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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