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Results for "

FAK inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FAK (76) Akt (4) Anaplastic lymphoma kinase (ALK) (4) Apoptosis (30) Aurora Kinase (1) Autophagy (6) c-Kit (3) c-Met/HGFR (5) CMV (3) COX (1) Cytochrome P450 (2) EGFR (6) ERK (3) FGFR (4) FLT3 (1) Glutaminase (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) HIV (2) HSP (1) HSV (1) IGF-1R (1) Insulin Receptor (1) Integrin (2) Isotope-Labeled Compounds (1) Ligands for Target Protein for PROTAC (1) MDM-2/p53 (2) MMP (4) mTOR (1) Necroptosis (1) NF-κB (5) p38 MAPK (2) PAK (1) Parasite (2) PDGFR (3) PI3K (2) PROTAC Linkers (1) PROTACs (6) Pyk2 (6) ROS Kinase (1) Sialyltransferase (1) Src (11) STAT (3) Syk (2) Topoisomerase (2) VEGFR (5)
By Research Areas:	Cancer (103) Cardiovascular Disease (2) Endocrinology (3) Infection (6) Inflammation/Immunology (7)

By Targets:

FAK (76)

Akt (4)

Anaplastic lymphoma kinase (ALK) (4)

Apoptosis (30)

Aurora Kinase (1)

Autophagy (6)

c-Kit (3)

c-Met/HGFR (5)

CMV (3)

COX (1)

Cytochrome P450 (2)

EGFR (6)

ERK (3)

FGFR (4)

FLT3 (1)

Glutaminase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (2)

HIV (2)

HSP (1)

HSV (1)

IGF-1R (1)

Insulin Receptor (1)

Integrin (2)

Isotope-Labeled Compounds (1)

Ligands for Target Protein for PROTAC (1)

MDM-2/p53 (2)

MMP (4)

mTOR (1)

Necroptosis (1)

NF-κB (5)

p38 MAPK (2)

PAK (1)

Parasite (2)

PDGFR (3)

PI3K (2)

PROTAC Linkers (1)

PROTACs (6)

Pyk2 (6)

ROS Kinase (1)

Sialyltransferase (1)

Src (11)

STAT (3)

Syk (2)

Topoisomerase (2)

VEGFR (5)

By Research Areas:

Cancer (103)

Cardiovascular Disease (2)

Endocrinology (3)

Infection (6)

Inflammation/Immunology (7)

104

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: FAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128580

FAK inhibitor 2 2 Publications Verification	FAK	Cancer
FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC₅₀  of 0.07 nM, with antitumor and anti-angiogenesis activities .

HY-12444

Y15 15+ Cited Publications FAK inhibitor 14	FAK	Cancer
Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth.

HY-155439

FAK-IN-14	FAK	Cancer
FAK-IN-14 (compound 8d) is a focal adhesion kinase(FAK) inhibitor with an IC₅₀ value of 0.2438 nM. FAK-IN-14 induces U87-MG cell early apoptosis and arrest the cell at the G2/M phase .

HY-144448

FAK-IN-2	FAK Apoptosis	Cancer
FAK-IN-2 is a potent and orally active focal adhesion kinase (FAK) inhibitor, with anticancer activity (FAK IC₅₀= 35 nM). FAK-IN-2 covalently inhibits the autophosphorylation of FAK in a dose-dependent manner, and inhibits the clone formation and migration of tumor cells, inducing apoptosis .

HY-162879

FAK inhibitor 7	FAK Src Akt Autophagy	Cancer
FAK inhibitor 7 is a type of *FAK* inhibitor with an IC₅₀ value of 3.58 nM. FAK inhibitor 7 can inhibit the downstream signaling cascades of FAK (like Src and AKT), causing ovarian cancer cells to stall in the G0/G1 phase and induce cytotoxic autophagy. FAK inhibitor 7 can also suppress tumor metastasis and growth in ovarian cancer mice .

HY-18928

FAK inhibitor 5	FAK	Cancer
FAK inhibitor 5 (compound 2) is a novel allosteric *FAK* inhibitor, with IC₅₀ values in the low micromolar range .

HY-146203

FAK inhibitor 6	FAK	Cancer
Compound 26F not only optimized the effective inhibitory enzyme (ic₅₀= 28.2 nm), but also showed relatively less cytotoxicity (ic₅₀= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase.

HY-157553

FAK-IN-19	FAK	Cancer
FAK-IN-19 (ligand3) is an inhibitor in a co-crystal structure with FAK. FAK-IN-19 has anticancer effects .

HY-155440

FAK-IN-15	FAK	Cancer
FAK-IN-15 (Compound 9b) is a focal adhesion kinase (FAK) inhibitor with an IC₅₀ value of 0.2691 nM. FAK-IN-15 has anti-tumor activity with an IC₅₀ value of 1.033 μM against U87-MG cells .

HY-12289S

Defactinib-d6 VS-6063-d₆; PF-04554878-d₆	FAK Isotope-Labeled Compounds	Cancer
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel *FAK* inhibitor with potential antiangiogenic and antineoplastic activities .

HY-164527

Si306	Src FAK EGFR	Cancer
Si306 is a Src inhibitor with antitumor activity. Si306 reduces the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), and inhibits the invasion of human glioblastoma (GBM) .

HY-169319

FAK-IN-21	FAK	Cancer
FAK-IN-21 (compound 9) is a *FAK* inhibitor with the IC₅₀ of 37.52 nM. FAK-IN-21 inhibits cell growth and the phosphorylation of FAK. FAK-IN-21 can be used for study of diffuse gastric cancer .

HY-156026

FAK-IN-11	FAK	Cancer
FAK-IN-11 (Compound 4l) is a *FAK* inhibitor. FAK-IN-11 binds to the ATP binding pocket of FAK, and inhibits phosphorylation of FAK protein. FAK-IN-11 shows cytotoxic activity against the MDA-MB-231 cells with an IC₅₀ of 13.73? μM. FAK-IN-11 induces non-apoptotic cell death in MDA-MB-231 cells .

HY-147520

FAK-IN-5	FAK Apoptosis Autophagy	Cancer
FAK-IN-5 (Compound 8l) is a FAK signaling inhibitor. FAK-IN-5 induces cell apoptosis and autophagy .

HY-146065

FAK-IN-4	FAK Apoptosis	Cancer
FAK-IN-4 (Compound 7d) is potential *FAK* inhibitor with anticancer activities. FAK-IN-4 induces cell apoptosis .

HY-150730

FAK-IN-6	FAK	Cancer
FAK-IN-6 is a potent *FAK* inhibitor with an IC₅₀ value of 1.415 nM. FAK-IN-6 has anti-proliferative activity against certain cancer cell lines. FAK-IN-6 can be used for researching pancreatic cancer .

HY-145108

FAK-IN-1	FAK	Cancer
FAK-IN-1 is a *FAK* inhibitor with anticancer activities (WO2020231726 (Example 27)) .

HY-143458

FAK PROTAC B5	FAK PROTACs	Cancer
FAK PROTAC B5 (Compound B5) is a *FAK* PROTAC degrader with an IC₅₀ value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion .

HY-117836

FAK-IN-16	FAK	Cancer
FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC₅₀ of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin (HY-17394) on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice .

HY-143407

FAK-IN-3	FAK	Cancer
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer .

HY-156334

FAK-IN-12	FAK	Cancer
FAK-IN-12 (Compound 12S) is a *FAK* inhibitor (IC₅₀ = 47 nM). FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC₅₀: 0.24, 0.45, 0.44 μM). FAK-IN-12 induces apoptosis and cellular senescence .

HY-10461

PF-573228 15+ Cited Publications	FAK Apoptosis	Cancer
PF-573228 is a potent and selective *FAK* inhibitor with IC₅₀ of 4 nM for purified recombinant catalytic fragment of FAK.

HY-149259

FAK-IN-9	FAK	Cancer
FAK-IN-9 (Compound 8f) is a potent and orally active *FAK* inhibitor with an IC₅₀ of 27.44 nM. FAK-IN-9 induces triple-negative breast cancer (TNBC) cell apoptosis .

HY-161358

FAK-IN-20	FAK Apoptosis	Cancer
FAK-IN-20 (Compound 7b) is an inhibitor of *FAK* with an IC₅₀ value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. FAK-IN-20 can arrest the cell cycle in the G2/M phase and induce cell apoptosis by generating ROS .

HY-148109

FAK-IN-7	FAK	Cancer
FAK-IN-7 (compound 5r) is a *FAK* inhibitor (IC₅₀=11.72 µM). FAK-IN-7 has good anti-proliferative activity and can be used in cancer research .

HY-148110

FAK-IN-8	FAK	Cancer
FAK-IN-8 (compound 5h) is a *FAK* inhibitor (IC₅₀=5.32 µM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research .

HY-162034

FAK-IN-17	FAK	Cancer
FAK-IN-17 is a focal adhesion kinase (FAK) inhibitor. FAK-IN-17 possesses anticancer activity against A549 and MDA-MB-231 cell lines with IC₅₀ values of 130 nM and 94 nM .

HY-12289A

Defactinib hydrochloride Maximum Cited Publications 37 Publications Verification VS-6063 hydrochloride; PF 04554878 hydrochloride	FAK	Cancer
Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel *FAK* inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.

HY-160447

FAK/aurora kinase-IN-1	Aurora Kinase FAK	Cancer
FAK/aurora kinase-IN-1 is a *FAK* and aurora kinase inhibitor with IC₅₀ values of 6.61 nM and 0.91 nM, respectively. FAK/aurora kinase-IN-1 shows anticancer effects (WO2018019252A1; compound 11) .

HY-153697

FAK-IN-10	FAK	Cancer
FAK-IN-10 is an inhibitor of *FAK* with an IC₅₀ of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC₅₀s of 4.23 and 0.78 μM,respectively .

HY-132296

GSK215	FAK PROTACs	Cancer
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC₅₀ of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect .

HY-15841

CEP-37440	Anaplastic lymphoma kinase (ALK) FAK	Cancer
CEP-37440 is a potent, orally active dual *FAK/ALK* inhibitor with IC₅₀ values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397) .

HY-109084

Conteltinib CT-707	FAK	Cancer
Conteltinib (CT-707) is a multi-kinase inhibitor targeting FAK, ALK, and Pyk2. Conteltinib exerts significant inhibitory effect on *FAK* with an IC₅₀ of 1.6 nM .

HY-100498A

GSK-2256098 hydrochloride 5 Publications Verification	Others	Cancer
GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival.

HY-155163

APG-2449	Anaplastic lymphoma kinase (ALK) ROS Kinase FAK	Others Cancer
APG-2449 is an orally active *ALK/ROS1/FAK* inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC) .

HY-163709

PROTAC FAK degrader 2	PROTACs FAK	Cancer
PROTAC FAK degrader 2 (Compound F2) is a PROTAC degrader for focal adhesion kinase (FAK), with DC₅₀ of 27.72 and 60.1 nM, for total *FAK* and phosphorylated *p-FAK. PROTAC FAK* degrader 2 inhibits cell viability of cancer cells 4T1, MDA-MB-231, MDA-MB-468 and MDA-MB-435, with IC₅₀s of 0.73-5.84 μM. PROTAC FAK degrader 2 reverses the multidrug resistance (MDR) through inhibition of AKT and ERK signaling pathway. PROTAC FAK degrader 2 exhibits antitumor efficacy in HCT/8 xenograft mouse model. (Pink: ligand for target protein Ifebemtinib (HY-122844); Black: linker (HY-Y0681); Blue: ligand for E3 ligase Thalidomide (HY-14658))

HY-N1372A

Fangchinoline 4 Publications Verification	HIV FAK Apoptosis Autophagy	Infection Cancer
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-124625

BI-4464	FAK Ligands for Target Protein for PROTAC	Infection Cancer
BI-4464 is a highly selective, ATP competitive *PTK2/FAK* protein kinase inhibitor with an IC₅₀ value of 17 nM. BI-4464 can be used as a PTK2 ligand for constructing proteolysis targeting chimeras (PROTAC).

HY-100498

GSK2256098 5 Publications Verification	FAK Apoptosis	Cancer
GSK2256098 is a selective *FAK* kinase inhibitor, which inhibits growth and survival of pancreatic ductal adenocarcinoma cells.

HY-157965

ZINC09875266	VEGFR FAK	Cancer
ZINC09875266 is a dual inhibitor targeting VEGFR2 and *FAK* that can be used in cancer research .

HY-122844

Ifebemtinib 1 Publications Verification BI-853520; IN-10018	FAK	Cancer
Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC₅₀=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC₅₀s of 900 nM and 1040 nM, respectively .

HY-12289

Defactinib Maximum Cited Publications 37 Publications Verification VS-6063; PF-04554878	FAK	Cancer
Defactinib (VS-6063; PF-04554878) is a novel *FAK* inhibitor with potential antiangiogenic and antineoplastic activities.

HY-103471

Y11	FAK	Cancer
Y11 inhibits *FAK1* autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth .

HY-N1372AR

Fangchinoline (Standard)	HIV FAK Apoptosis Autophagy	Infection Cancer
Fangchinoline (Standard) is the analytical standard of Fangchinoline. This product is intended for research and analytical applications. Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-B1305

Chloropyramine hydrochloride	FAK Histamine Receptor VEGFR	Endocrinology Cancer
Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3 and *FAK*.

HY-145652

Narmafotinib AMP-945	FAK	Cancer
Narmafotinib (AMP-945) is an inhibitor of the enzyme focal adhesion kinase (FAK, K_D=0.21 nM). Narmafotinib inhibits autophosphorylation of 397Y-FAK in MDA-MB-231 cells with an IC₅₀=7 nM and exhibits low general cellular toxicity (IC₅₀=2.7 μM, MDA-MB-231 cells) .

HY-401485

Pyk2-IN-2	Pyk2 FAK	Cancer
Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC₅₀ of FAK kinase of 0.608 μM .

HY-10458

PF-562271 besylate 15+ Cited Publications VS-6062 besylate	FAK Pyk2	Cancer
PF-562271 (VS-6062) besylate is a potent ATP-competitive, reversible inhibitor of *FAK* and Pyk2 kinase, with an IC₅₀ of 1.5 nM and 13 nM, respectively .

HY-122965

Batatasin III	FAK Akt	Cancer
Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and *FAK-AKT* signals. Batatasin III has anti-cancer activities .

HY-117595

PHM16	FAK FGFR Apoptosis	Cancer
PHM16 is an ATP competitive inhibitor of *FAK* and FGFR2 (IC₅₀: 0.4 μM and 0.37 μM, respectively), with direct potent anti-angiogenic activity .

Cat. No.	Product Name	Type

HY-W008907

5'-O-Tritylthymidine 5-OTT	Gene Sequencing and Synthesis
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

Cat. No.	Product Name	Target	Research Area

HY-P10323

T7 Peptide Tumstatin (74-98), human	Integrin FAK mTOR Apoptosis	Cancer
T7 peptide is an endothelial cell-specific inhibitor. T7 peptide interacts with αVβ3 integrin to inhibit the *FAK, PI3-kinase, PKB/Akt, and mTOR* signaling pathways in endothelial cells, ultimately suppressing protein synthesis and inducing apoptosis .

HY-P5910

Azurin p28 peptide	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide is a tumor-penetrated antitumor peptide. Azurin p28 peptide redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide induces apoptosis or cell cycle arrest. Azurin p28 peptide inhibits p53-positive tumor growths. Azurin p28 peptide shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

HY-P5910A

Azurin p28 peptide TFA	MDM-2/p53 Apoptosis	Cancer
Azurin p28 peptide TFA is a tumor-penetrated antitumor peptide. Azurin p28 peptide TFA redues proteasomal degradation of p53 through formation of a p28: p53 complex. Azurin p28 peptide TFA induces apoptosis or cell cycle arrest. Azurin p28 peptide TFA inhibits p53-positive tumor growths. Azurin p28 peptide TFA shows antiangiogenic effect by inhibiting phosphorylation of VEGFR-2, FAK and Akt .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1372A

Fangchinoline 4 Publications Verification	Stephania tetrandra S. Moore Infection Alkaloids Structural Classification Monophenols Classification of Application Fields Source classification Phenols Plants Isoquinoline Alkaloids Menispermaceae Disease Research Fields	HIV FAK Apoptosis Autophagy
Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-122965

Batatasin III	Natural Products other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	FAK Akt
Batatasin III, a stilbenoid, inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition (EMT) and *FAK-AKT* signals. Batatasin III has anti-cancer activities .

HY-N4127

3'-Demethylnobiletin	Monophenols Flavonoids Classification of Application Fields Flavones Source classification Rutaceae Phenols Plants Disease Research Fields Citrus Cancer	Src STAT
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits . Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling .

HY-N0896

Inulicin 1 Publications Verification 1-O-Acetylbritannilactone	Phyllodium pulchellum (L.) Desv. Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	NF-κB COX
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and *FAK. Inulicin (1-O-Acetylbritannilactone) inhibits* LPS-induced PGE₂ production and COX-2 expression, and NF-κB activation and translocation.

HY-N1127

Tricin 2 Publications Verification	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Agrostidoideae Source classification Phenols Polyphenols Plants Disease Research Fields Triticum aestivum L.	CMV
Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-N10335

Harringtonolide 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Cephalotaxus harringtonia Plants Cephalotaxaceae Inflammation/Immunology Disease Research Fields Cancer	FAK
Harringtonolide is a potent RACK1 inhibitor (IC₅₀=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between *FAK* and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities .

HY-N0498

Nitidine chloride 3 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and *c-Src/FAK* associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N1372AR

Fangchinoline (Standard)	Stephania tetrandra S. Moore Alkaloids Structural Classification Monophenols Source classification Phenols Plants Isoquinoline Alkaloids Menispermaceae	HIV FAK Apoptosis Autophagy
Fangchinoline (Standard) is the analytical standard of Fangchinoline. This product is intended for research and analytical applications. Fangchinoline is isolated from Stephania tetrandra with extensive biological activities, such as enhancing immunity, anti-inflammatory sterilization and anti-atherosclerosis. Fangchinoline, a novel HIV-1 inhibitor, inhibits HIV-1 replication by impairing gp160 proteolytic processing . Fangchinoline targets Focal adhesion kinase (FAK) and suppresses FAK-mediated signaling pathway in tumor cells which highly expressed FAK . Fangchinoline induces apoptosis and adaptive autophagy in bladder cancer .

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N1127R

Tricin (Standard)	Structural Classification Flavonoids Flavones Agrostidoideae Source classification Phenols Polyphenols Plants Triticum aestivum L.	CMV
Tricin (Standard) is the analytical standard of Tricin. This product is intended for research and analytical applications. Tricin is a natural flavonoid found in large amounts in wheat. Tricin inhibits HCMV replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells by upregulating the expression of FAK-targeting microRNA-7 .

HY-N0498R

Nitidine chloride (Standard)	Alkaloids Structural Classification Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Plants Isoquinoline Alkaloids	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB
Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride). This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway .

HY-N8380

(-)-Latifolin	Structural Classification Dalbergia hupeana Hance Source classification Phenols Polyphenols Plants Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

Cat. No.	Product Name	Chemical Structure

HY-12289S

Defactinib-d6
Defactinib-d6 is a deuterium labeled Defactinib (HY-12289). Defactinib is a novel *FAK* inhibitor with potential antiangiogenic and antineoplastic activities .

HY-N1127S

Tricin-d6
Tricin-d₆ is the deuterium labeled Tricin[1]. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7[2][3][4].

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