2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. AK963/40708899

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways.

For research use only. We do not sell to patients.

AK963/40708899 Chemical Structure

AK963/40708899 Chemical Structure

CAS No. : 445007-59-0

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AK963/40708899 Related Antibodies

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PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

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Description

AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways[1].

IC50 & Target[1]

PAK1

 

Molecular Weight

254.33

Formula

C16H18N2O
CAS No.
SMILES

O=C(NC1=CC(C)=CC=C1C)NC2=CC=CC(C)=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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AK963/40708899 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AK963/40708899445007-59-0PAKp21 activated kinasesgastric cancer cellPAK1-NF-κB-cyclinB1cycle arrestG2 phasemigrationinvasionfilopodiaPAK1-LIMKl-cofilinPAK1-ERK-FAKInhibitorinhibitorinhibit

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