Sialyltransferase

Sialyltransferases are enzymes that transfer sialic acid to nascent oligosaccharides. Sialyltransferases (SiaTs) exhibit distinct characteristics and preferences, such as for substrates and glycosidic linkages. Sialyltransferases use cytidine monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) as an activated sugar donor. Overexpression of sialyltransferases is associated with tumor hypersialylation and poor outcome^[1].

References:

[1]. Marjolaine Hugonnet, et al. The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology. Front Immunol. 2021 Dec 17:12:799861. [Content Brief]

Sialyltransferase Inhibitor (1)

Sialyltransferase Related Products (10):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-110288

3FAx-Neu5Ac		99.88%
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.

HY-112415

Lith-O-Asp		≥98.0%
Lith-O-Asp is a sialytransferase (ST) inhibitor, with IC₅₀s of 12-37 μM.

HY-112535

α-2,3-sialyltransferase-IN-1		≥98.0%
α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC₅₀ of 6 μM.

HY-E70024

CMP-sialic acid synthetase (NmCSS)
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases.

HY-E70055

α-2,6-Sialyltransferase, pasteurella multocida (P-1059)
alpha-2,6-Sialyltransferase (Pd26ST) (EC 2.4.99.1) is capable of sialylating both terminal and internal galactose and N-acetylgalactosamine, which producing terminal α2,6-sialosides.

HY-E70056

α2,3-Sialyltransferase, Pasteurella multocida (P-1059)
α2,3-Sialyltransferase, Pasteurella multocida (P-1059) (PmST1(M144D)), a sialyltransferase, can be isolated from Pasteurella multocida. alpha-2,3-Sialyltransferase (PmST1) can be converted into regioselective α2-6-sialyltransferase by saturation mutagenesis and regioselective screening.

HY-101218

N-Biotinyl-6-aminohexanoic acid		99.84%
N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) can be used to perform biotinylation.

HY-E70065

alpha-2,3-Sialyltransferase (PmST2)
alpha-2,3-Sialyltransferase (PmST2) is a sialyltransferase produced by Pasteurella multocida (Pm) and plays an important role in the pathogenesis of Pm. alpha-2,3-Sialyltransferase (PmST2) can be used to synthesize sialyllactosyl sphingosine (lyso-GM3).

HY-E70150

ST6 Sialyltransferase 1
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer.

HY-163548

SPP-002	Inhibitor	≥98.0%
SPP-002 is a sulfate analogue that acts as a potential Sialyltransferase (ST) inhibitor. SPP-002 selectively inhibits n-glycosialylation with inhibition at least an order of magnitude greater than that of unmodified parental cholic acid (LCA). SPP-002 reduces tumor cell migration and invasion by inhibiting the integrin /FAK/Paxillin signaling pathway. SPP-002 can be used in the study of tumor metastasis.

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