2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. Y11

Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth.

For research use only. We do not sell to patients.

Y11 Chemical Structure

Y11 Chemical Structure

CAS No. : 1086639-59-9

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Based on 1 publication(s) in Google Scholar

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Description

Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth[1].

Molecular Weight

265.15

Formula

C8H17BrN4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC[N+]12C[N@](C3)C[N@](C[N@]3C2)C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (37.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7715 mL 18.8573 mL 37.7145 mL
5 mM 0.7543 mL 3.7715 mL 7.5429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7715 mL 18.8573 mL 37.7145 mL 94.2863 mL
5 mM 0.7543 mL 3.7715 mL 7.5429 mL 18.8573 mL
10 mM 0.3771 mL 1.8857 mL 3.7715 mL 9.4286 mL
15 mM 0.2514 mL 1.2572 mL 2.5143 mL 6.2858 mL
20 mM 0.1886 mL 0.9429 mL 1.8857 mL 4.7143 mL
25 mM 0.1509 mL 0.7543 mL 1.5086 mL 3.7715 mL
30 mM 0.1257 mL 0.6286 mL 1.2572 mL 3.1429 mL
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Y11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y111086639-59-9Y 11Y-11FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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