GSK-2256098 hydrochloride

Name: GSK-2256098 hydrochloride
Brand: MedChemExpress
SKU: HY-100498A
Rating: 5.0 (5 reviews)

Cat. No.: HY-100498A Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival.

For research use only. We do not sell to patients.

GSK-2256098 hydrochloride Chemical Structure

CAS No. : 1416771-10-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of GSK-2256098 hydrochloride:

GSK2256098 In-stock

5 Publications Citing Use of MCE GSK-2256098 hydrochloride

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

451.35

Formula

C₂₀H₂₄Cl₂N₆O₂

CAS No.

1416771-10-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NOC)C1=CC=CC=C1NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (221.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2156 mL	11.0779 mL	22.1558 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (11.08 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) HNMR (146 KB) RP-HPLC (168 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2156 mL	11.0779 mL	22.1558 mL	55.3894 mL
	5 mM	0.4431 mL	2.2156 mL	4.4312 mL	11.0779 mL
	10 mM	0.2216 mL	1.1078 mL	2.2156 mL	5.5389 mL
	15 mM	0.1477 mL	0.7385 mL	1.4771 mL	3.6926 mL
	20 mM	0.1108 mL	0.5539 mL	1.1078 mL	2.7695 mL
	25 mM	0.0886 mL	0.4431 mL	0.8862 mL	2.2156 mL
	30 mM	0.0739 mL	0.3693 mL	0.7385 mL	1.8463 mL
	40 mM	0.0554 mL	0.2769 mL	0.5539 mL	1.3847 mL
	50 mM	0.0443 mL	0.2216 mL	0.4431 mL	1.1078 mL
	60 mM	0.0369 mL	0.1846 mL	0.3693 mL	0.9232 mL
	80 mM	0.0277 mL	0.1385 mL	0.2769 mL	0.6924 mL
	100 mM	0.0222 mL	0.1108 mL	0.2216 mL	0.5539 mL