2. Apoptosis PI3K/Akt/mTOR Autophagy
  3. Autophagy Apoptosis PI3K Necroptosis
  4. (-)-Latifolin

(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities.

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(-)-Latifolin Chemical Structure

(-)-Latifolin Chemical Structure

CAS No. : 10154-42-4

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(-)-Latifolin Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
73.2 μM
Compound: 19
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
[PMID: 23743282]
Molecular Weight

286.32

Formula

C17H18O4
CAS No.
SMILES

OC1=CC([C@@H](C2=CC=CC=C2O)C=C)=C(OC)C=C1OC
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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(-)-Latifolin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Latifolin10154-42-4AutophagyApoptosisPI3KNecroptosisPhosphoinositide 3-kinaseflavonoidproliferationoral squamous cell carcinomaOSCCanti-metastaticmigrationinvasionadhesionFAK/Srcautophagosomedephosphorylating necroptosisRIP1RIP3MLKLanti-aginganti-carcinogenicanti-inflammatorycardio-protectiveInhibitorinhibitorinhibit

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