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Results for "

FPG

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antifolate (1) Endogenous Metabolite (1) P2X Receptor (1) P2Y Receptor (1) SGLT (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Metabolic Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Remogliflozin etabonate GSK189075	SGLT	Metabolic Disease
Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with K_i values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .

FPGS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FPGS Human Pre-designed siRNA Set A contains three designed siRNAs for FPGS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FPGS Human Pre-designed siRNA Set A FPGS Human Pre-designed siRNA Set A

*Blue FPG-A trisodium*	P2X Receptor P2Y Receptor	Inflammation/Immunology
Blue FPG-A trisodium is a selective antagonist of P2X₁ receptor and P2Y₁ receptor with IC₅₀ values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2) .

AMPte-Glu-γ-Glu	Antifolate Others	Cancer
AMPte-Glu-γ-Glu is a substrate for folylpoly-γ-glutamate synthetase (FPGS). AMPte-Glu-γ-Glu exhibits cytotoxicity against chinese hamster ovaries cells, with IC₅₀s of 20, 350 and 3 nM, for Pro3, R2, and 43-10, respectively .

AMG-151 ARRY-403	Endogenous Metabolite	Metabolic Disease
AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes .

Cat. No.	Compare	Product Name	Species	Source

	NEIL1 Protein, Human (His) Endonuclease 8-like 1; Endonuclease VIII-like 1; FPG1; NEH1; NEIL1	Human	E. coli
	NEIL1 is a critical base excision repair enzyme that recognizes and eliminates damaged bases and preferentially selects oxidized pyrimidines such as thymine glycol, Fapy, and 5-hydroxyuracil. Although NEIL1 has limited activity toward 8-oxoguanine, it has excellent AP lyase activity and introduces nicking by eliminating β-δ. NEIL1 Protein, Human (His) is the recombinant human-derived NEIL1 protein, expressed by E. coli , with C-His labeled tag. The total length of NEIL1 Protein, Human (His) is 390 a.a., with molecular weight of ~45 kDa.

	FPG Protein, E.coli (His)	E.coli	E. coli
	FPG is a key base excision repair enzyme that recognizes and eliminates damaged bases, especially oxidized purines such as 8-oxoG. It acts on a variety of pathologies, including guanidinohydantoin: C, spiroiminodiahydantoin: C, thymine glycol: G, 5,6-dihydrouracil: G, and 5-hydroxy Uracil: G. FPG Protein, E.coli (His) is the recombinant E. coli-derived FPG protein, expressed by E. coli , with His tag. FPG Protein, E.coli (His), has molecular weight of ~30.3 kDa.

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FPGS Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
FPGS Human Pre-designed siRNA Set A contains three designed siRNAs for FPGS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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