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Results for "

FTH1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Ferroptosis (1) MDM-2/p53 (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MMRi62	Ferroptosis Apoptosis Autophagy MDM-2/p53	Cancer
MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 ^[1] .

FTH1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FTH1 Human Pre-designed siRNA Set A contains three designed siRNAs for FTH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FTH1 Human Pre-designed siRNA Set A FTH1 Human Pre-designed siRNA Set A

Cat. No.	Compare	Product Name	Species	Source

	*Ferritin heavy chain/FTH1* Protein, Human** rHuFerritin heavy chain/FTH1; Ferritin heavy chain; FTH1; FTH; FTHL6; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	Human	E. coli
	The ferritin heavy chain/FTH1 protein is critical for maintaining iron homeostasis, storing iron in soluble form through ferroxidase activity. It promotes the oxidation of ferrous iron so that it can be deposited in the form of iron hydroxide. Ferritin heavy chain/FTH1 Protein, Human is the recombinant human-derived Ferritin heavy chain/FTH1 protein, expressed by E. coli , with tag free. The total length of Ferritin heavy chain/FTH1 Protein, Human is 183 a.a., with molecular weight of ~22.34 kDa.

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	Ferritin Heavy Chain Antibody FTH1; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin heavy chain; Ferritin H subunit; Cell proliferation-inducing gene 15 protein	WB, ICC/IF	Human, Mouse, Rat, Hamster
	Ferritin Heavy Chain Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 21 kDa, targeting to Ferritin Heavy Chain. It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat, Hamster.

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Cat. No.	Product Name		Classification

FTH1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
FTH1 Human Pre-designed siRNA Set A contains three designed siRNAs for FTH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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