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Results for "

FTH1

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148409
    MMRi62

    		Ferroptosis Apoptosis Autophagy MDM-2/p53 Cancer
    MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 [1] .
    MMRi62
  • HY-RS05133
    FTH1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FTH1 Human Pre-designed siRNA Set A contains three designed siRNAs for FTH1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FTH1 Human Pre-designed siRNA Set A
    FTH1 Human Pre-designed siRNA Set A
  • HY-168894
    CT-1

    		Ferroptosis Cancer
    CT-1 is a derivative of Cryptotanshinone (HY-N0174). CT-1 is a ferroptosis inducer. CT-1 promotes the interaction between NCOA4 and ferritin by targeting FTH1, triggering ferritinophagy-mediated ferroptosis. CT-1 has anticancer activity against triple-negative breast cancer (TNBC). CT-1 induces ferroptosis in both N2-type tumor-associated neutrophils (TANs) and TNBC cancer cells [1].
    CT-1

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