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FXIIa-IN-5

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-162646
    FXIIa-IN-5

    		Thrombin Cardiovascular Disease
    FXIIa-IN-5 (Compound 4J) is an orally active, selective inhibitor for factor XIIa (FXIIa), with IC50 of 21 nM. FXIIa-IN-5 inhibits the intrinsic coagulation pathways, and exhibits anti-inflammatory and antithrombotic activity in Carrageenan (HY-125474)-induced mice thrombosis models. FXIIa-IN-5 exhibits moderate pharmacokinetic characteristics and slightly toxicity (at 100 mg/kg) .
    FXIIa-IN-5

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