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Glutaminyl cyclases-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151132
    Glutaminyl cyclases-IN-1

    IsoQC-IN-1

    		 CD47 Cancer
    Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .
    Glutaminyl cyclases-IN-1
  • HY-112269
    Glutaminyl Cyclase Inhibitor 1

    		Amyloid-β Neurological Disease
    Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor with an IC50 of 0.5 μM.
    Glutaminyl Cyclase Inhibitor 1
  • HY-101282
    Glutaminyl Cyclase Inhibitor 3

    		Amyloid-β Neurological Disease
    Glutaminyl Cyclase Inhibitor 3 (compound 212 ), a designed anti-Alzheimer’s compound, is a potent human Glutaminyl Cyclase (GC) inhibitor, with an IC50 of 4.5 nM. Glutaminyl Cyclase-IN-1 (compound 212) significantly reduced the brain concentrations of pyroform Aβ and total Aβ and restored cognitive functions .
    Glutaminyl Cyclase Inhibitor 3

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