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HPK1-IN-56

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-172107
    HPK1-IN-56

    		MAP4K Inflammation/Immunology Cancer
    HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM). HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells). HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody .
    HPK1-IN-56

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