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Results for "

Human Factor XIa

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118969
    BMS-262084

    		Factor Xa Ser/Thr Protease Cardiovascular Disease
    BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects .
    BMS-262084
  • HY-137431
    Asundexian
    1 Publications Verification

    BAY-2433334

    		 Factor Xa Cardiovascular Disease
    Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM .
    Asundexian
  • HY-125856
    Milvexian
    1 Publications Verification

    BMS-986177; JNJ-70033093

    		 Factor Xa Cardiovascular Disease
    Milvexian is an orally bioavailable, small-molecule, reversible, direct antagonists of factor Xia, with the Ki of 0.11, 0.38, 0.64, 490, 350 nM for human, rabbit, dog, rat, mouse, respectively. Milvexian shows anti-thrombosis activity in vitro and in vivo, and can be used for thrombus study .
    Milvexian
  • HY-E70393C
    Human Factor XIa

    		Others Others
    Human Factor XIa is a blood coagulation protease. Human Factor XIa activates the Factor IX and Factor V, resulting in the generation of thrombin and fibrin .
    Human Factor XIa
  • HY-12631
    BMS-654457

    		Factor Xa Cardiovascular Disease
    BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively.
    BMS-654457

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