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Indole-3-carboxylic acid

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By Targets:	AMPK (1) Cannabinoid Receptor (1) CD38 (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (3) Phosphodiesterase (PDE) (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (3) Neurological Disease (1)

11

Inhibitors & Agonists

1

Peptides

2

Natural
Products

3

Isotope-Labeled Compounds

Targets Recommended: Carboxylesterase (CES) Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Indole-3-carboxylic acid	Endogenous Metabolite	Metabolic Disease
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

Indole-3-carboxylic acid (Standard)	Endogenous Metabolite	Metabolic Disease
Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

Indole-3-carboxylic acid-d4	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Indole-3-carboxylic acid-d₄ is deuterium labeled Indole-3-carboxylic acid. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-W000793S

*5-Methoxy-1H-indole-3-carboxylic* acid-d3**	Isotope-Labeled Compounds	Others
5-Methoxy-1H-indole-3-carboxylic acid-d₃ is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].

*1-(5-Fluoropentyl)-1H-indole-3-carboxylic* acid-d5** 5F-PB-223-CarboxyIndolemetabolite-d₅	Isotope-Labeled Compounds	Others
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d₅ (5F-PB-223-Carboxyindolemetabolite-d₅) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid .

Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate 1-(Cyclohexylmethyl)-1H-Indole-3-carboxylic acid Methyl Ester	Cannabinoid Receptor	Neurological Disease
Methyl-1-(cyclohexylmethyl)-1H-indole-3-carboxylate (1-(Cyclohexylmethyl)-1H-indole-3-carboxylic Acid Methyl Ester) is an analog of BB-22 that lacks the quinoline group. BB-22 is an analog of cannabinoid .

AMPK-α1β1γ1 activator 1	AMPK	Cardiovascular Disease
AMPK-α1β1γ1 activator 1 (M1) is an acyl glucuronide metabolite of Indole-3-carboxylic Acid-based AMPK activator. AMPK-α1β1γ1 activator 1 can selectively activated human β1 isoforms with an EC₅₀ value of 38.1nM. AMPK-α1β1γ1 activator 1 can direct binding with human AMPK α1β1γ1 isoform. AMPK-α1β1γ1 activator 1 can be used for the research of diabetic nephropathy .

ATX inhibitor 19	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 156 nM .

ATX inhibitor 21	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 21 (compound 8) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 3490 nM .

ATX inhibitor 20	Phosphodiesterase (PDE)	Cancer
ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM .

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Target	Research Area

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

Indole-3-carboxylic acid	Alkaloids Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

Indole-3-carboxylic acid (Standard)	Alkaloids Structural Classification Human Gut Microbiota Metabolites Source classification Endogenous metabolite Indole Alkaloids	Endogenous Metabolite
Indole-3-carboxylic acid (Standard) is the analytical standard of Indole-3-carboxylic acid. This product is intended for research and analytical applications. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

Cat. No.	Product Name	Chemical Structure

Indole-3-carboxylic acid-d4
Indole-3-carboxylic acid-d₄ is deuterium labeled Indole-3-carboxylic acid. Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases .

HY-W000793S

*5-Methoxy-1H-indole-3-carboxylic* acid-d3**
5-Methoxy-1H-indole-3-carboxylic acid-d₃ is the deuterium labeled 5-methoxy-1H-indole-3-carboxylic acid[1].

*1-(5-Fluoropentyl)-1H-indole-3-carboxylic* acid-d5**
1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid-d₅ (5F-PB-223-Carboxyindolemetabolite-d₅) is deuterium labeled 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid .

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