LAR

By Targets:	Estrogen Receptor/ERR (1) Formyl Peptide Receptor (FPR) (1) Phosphatase (3) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (6)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131180

BMS-986235 1 Publications Verification LAR-1219	Formyl Peptide Receptor (FPR)	Cardiovascular Disease
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC₅₀s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure .

HY-136242

UT-34	Estrogen Receptor/ERR	Endocrinology Cancer
UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC₅₀ values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, *F876L-AR, and W741L-AR*, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

HY-RS21628

Lars2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lars2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lars2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lars2 Mouse Pre-designed siRNA Set A Lars2 Mouse Pre-designed siRNA Set A

HY-RS07532

LARS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LARS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LARS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LARS1 Human Pre-designed siRNA Set A LARS1 Human Pre-designed siRNA Set A

HY-RS28146

Lars2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lars2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lars2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lars2 Rat Pre-designed siRNA Set A Lars2 Rat Pre-designed siRNA Set A

HY-RS21627

Lars1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lars1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lars1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lars1 Mouse Pre-designed siRNA Set A Lars1 Mouse Pre-designed siRNA Set A

HY-RS07533

LARS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LARS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LARS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LARS2 Human Pre-designed siRNA Set A LARS2 Human Pre-designed siRNA Set A

HY-RS28145

Lars1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lars1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lars1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lars1 Rat Pre-designed siRNA Set A Lars1 Rat Pre-designed siRNA Set A

HY-N12776

Illudalic acid	Phosphatase	Cancer
Illudalic acid is a potent and selective *Leukocyte antigen-related (LAR) phosphatase* inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

HY-N12177

Cryptosporioptide A	Phosphatase	Metabolic Disease
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

HY-119019

ASB14780 1 Publications Verification	Phosphatase	Inflammation/Immunology
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A₂α (cPLA₂α) inhibitor, with an IC₅₀ value of 20 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12776

Illudalic acid	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Phosphatase
Illudalic acid is a potent and selective *Leukocyte antigen-related (LAR) phosphatase* inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

HY-N12177

Cryptosporioptide A	Structural Classification Flavonoids Microorganisms Source classification Other Flavonoids	Phosphatase
Cryptosporioptide A (Compound 3) is a pigment protein tyrosine phosphatase inhibitor derived from the insect-parasitic fungus Cordyceps gracilioides. Cryptosporioptide A inhibits PTP1B, SHP2, CDC25B, LAR and SHP1 enzymes with IC₅₀ of 7.3, 5.7, 7.6, >50, 4.9 μg/mL, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84047

	PTPRF Antibody (YA3744) LAR; BNAH2	FC	Human

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Cat. No.	Product Name		Classification

HY-RS21628

Lars2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lars2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lars2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07532

LARS1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LARS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LARS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28146

Lars2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lars2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lars2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21627

Lars1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lars1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lars1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07533

LARS2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LARS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LARS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS28145

Lars1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lars1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lars1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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