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LIFR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) FXR (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

4

Inhibitors & Agonists

6

Recombinant Proteins

1

Click Chemistry

2

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

EC359 5+ Cited Publications	Apoptosis	Cancer
EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a K_d of 10.2 nM, which directly interacts with *LIFR* to effectively block LIF/LIFR interactions . EC359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Lifr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Lifr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lifr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lifr Mouse Pre-designed siRNA Set A Lifr Mouse Pre-designed siRNA Set A

LIFR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LIFR Human Pre-designed siRNA Set A contains three designed siRNAs for LIFR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LIFR Human Pre-designed siRNA Set A LIFR Human Pre-designed siRNA Set A

BAR-2227	FXR	Inflammation/Immunology
BAR-2227 (compound 3a) is a FXR agonist and *LIFR* inhibitor. BAR-2227 can be used to study liver fibrosis and inflammation .

Species:	Human (4) Rat (1) Mouse (1)
Tag:	His (4) Fc (2) Flag (1)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

	LIFR Protein, Rat (HEK293, His) Leukemia inhibitory factor receptor; LIF-R; CD118	Rat	HEK293
	LIFR protein is an important member of the type I cytokine receptor family, mediating cellular responses to a variety of cytokines, emphasizing its role in cell differentiation and immune regulation. LIFR Protein, Rat (HEK293, His) is the recombinant rat-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

	LIFR Protein, Human (HEK293, Fc) Leukemia inhibitory factor receptor; LIF-R; CD118	Human	HEK293
	LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, Fc) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-hFc labeled tag.

	LIFR Protein, Human (HEK293, His) Leukemia inhibitory factor receptor; LIF-R; CD118	Human	HEK293
	LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, His) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

	LIFR Protein, Mouse (HEK293, His) Leukemia inhibitory factor receptor; LIF-R; CD118	Mouse	HEK293
	LIFR Protein, a signal-transducing molecule, may share a common pathway with IL6ST. Its soluble form acts as an inhibitor, blocking LIF binding to receptors and reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, indicating potential cross-talk and cooperative actions in cellular processes. LIFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

	LIFR Protein, Human (Biotinylated, HEK293, His) Leukemia inhibitory factor receptor; LIF-R; CD118	Human	HEK293
	LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.

	LIFR Protein, Human (HEK293, hFc-Flag) LIFR; leukemia inhibitory factor receptor alpha; leukemia inhibitory factor receptor; CD118; LIF receptor; CD118 antigen; SWS; SJS2; STWS; LIF-R; FLJ98106; FLJ99923	Human	HEK293
	LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-hFc, C-Flag labeled tag.

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Cat. No.	Product Name		Classification

EC359 5+ Cited Publications		Alkynes
EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a K_d of 10.2 nM, which directly interacts with *LIFR* to effectively block LIF/LIFR interactions . EC359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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