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Results for "

LXR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	LXR (48) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (5) Estrogen Receptor/ERR (2) Fatty Acid Synthase (FASN) (1) Free Fatty Acid Receptor (1) FXR (1) Glucocorticoid Receptor (2) iGluR (2) Interleukin Related (2) Na+/K+ ATPase (1) Nucleoside Antimetabolite/Analog (1) PPAR (2) RAR/RXR (1) ROR (2) Sirtuin (2) Stearoyl-CoA Desaturase (SCD) (1) VD/VDR (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (15) Endocrinology (2) Inflammation/Immunology (9) Metabolic Disease (21) Neurological Disease (4)

By Targets:

LXR (48)

Apoptosis (3)

Aryl Hydrocarbon Receptor (1)

Drug-Linker Conjugates for ADC (1)

Endogenous Metabolite (5)

Estrogen Receptor/ERR (2)

Fatty Acid Synthase (FASN) (1)

Free Fatty Acid Receptor (1)

FXR (1)

Glucocorticoid Receptor (2)

iGluR (2)

Interleukin Related (2)

Na+/K+ ATPase (1)

Nucleoside Antimetabolite/Analog (1)

PPAR (2)

RAR/RXR (1)

ROR (2)

Sirtuin (2)

Stearoyl-CoA Desaturase (SCD) (1)

VD/VDR (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (15)

Endocrinology (2)

Inflammation/Immunology (9)

Metabolic Disease (21)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: LXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-144549

LXR agonist 1	LXR	Cardiovascular Disease
LXR (Liver X receptor) agonist 1 is potent *LXR* agonist with AC₅₀s of 1.5 nM and 12 nM for *LXR-α* and *LXR-β, respectively. LXR* agonist 1 has the potential for the research of atherosclerosis .

HY-10629

LXR-623 5+ Cited Publications WAY 252623	LXR	Metabolic Disease Cancer
LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC₅₀s of 24 nM and 179 nM, respectively.

HY-160039

GAC0001E5	LXR	Cancer
GAC0001E5 is an *LXR* inverse agonist. GAC0001E5 has antiproliferative activity and can be used in cancer research .

HY-N2509

Iristectorigenin B Iristectrigenin B	LXR	Cardiovascular Disease
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-146288

LXR agonist 2	LXR	Metabolic Disease
LXR agonist 2 (compound 18rr) is a potent *LXR* (liver X receptor) agonist. LXR agonist 2 can stabilize NCOA1 (co-activator), leading to LXR agonism .

HY-146275

LXRβ agonist-3	LXR	Cancer
LXRβ agonist-3 (compound 4-13) is a potent and selective LXRβ (liver X receptor β) agonist, with an EC₅₀ of 0.095 μM. LXRβ agonist-3 efficiently inhibits U87EGFRvIII cell, with an IC₅₀ of 3.75 μM. LXRβ agonist-3 shows antitumor activity, and can inhibit glioblastoma .

HY-100469

LXRβ agonist-2	LXR	Cardiovascular Disease
LXRβ agonist-2 is a highly potent and β-selective liver X receptor *(LXRβ)* agonist with EC₅₀ of 7 nM, displays 28.5-fold selectivity over LXRα (EC₅₀=200 nM) and used in the treatment of atherosclerosis .

HY-144554

Aminooxy CatB-LXR	Drug-Linker Conjugates for ADC	Cancer
Aminooxy CatB-LXR (compound 10) is a agent-linker conjugates for ADC .

HY-W754708

Ouabagenin	LXR Na+/K+ ATPase	Cardiovascular Disease
Ouabagenin is a naturally occurring *LXR* ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-14353

GSK-9772	LXR	Neurological Disease Inflammation/Immunology
GSK-9772 is a Liver X Receptor (LXR) modulator of the N-phenyl tertiary amine class (NPTAs) with high affinity for LXR β ligand (IC₅₀=30 nM). GSK-9772 has anti-inflammatory activity by binding to *LXR*, specifically by interacting with the region associated with the transcriptional repression function of the receptor, thereby inhibiting the expression of pro-inflammatory genes. GSK-9772 can be used in the study of inflammatory and neurodegenerative diseases .

HY-116969

22(R)-Hydroxycholesterol Narthesterol	LXR	Metabolic Disease
22(R)-Hydroxycholesterol (Narthesterol) is an endogenous *LXR* agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research .

HY-N2078

Yamogenin Neodiosgenin	LXR	Metabolic Disease
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N2078R

Yamogenin (Standard)	LXR	Metabolic Disease
Yamogenin (Standard) is the analytical standard of Yamogenin. This product is intended for research and analytical applications. Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-169159

SIRT6 activator 2	Sirtuin	Metabolic Disease
SIRT6 activator 2 (compound 31) is a sirtuin 6 activator with anti-lipid accumulation properties. SIRT6 activator 2 significantly downregulates LXR, SREBP-1c, and their target genes associated with lipogenesis, and can be used for research related to lipid metabolism-related diseases .

HY-19919

BMS-779788 1 Publications Verification EXEL04286652; XL-652; BMS-788	LXR	Metabolic Disease
BMS-779788 is a *LXR* partial agonist with IC₅₀ values of 68 nM for LXRα and 14 nM for LXRβ.

HY-108688

GSK2033 20+ Cited Publications	LXR	Metabolic Disease
GSK2033 is a *LXR* antagonist with pIC₅₀s of 7 and 7.4 for LXRα or LXRβ, respectively.

HY-101442

SR9238	LXR	Metabolic Disease
SR9238 is a synthetic liver X receptor (LXR) inverse agonist with IC₅₀s of 214 nM and 43 nM for LXRα and LXRβ, respectively.

HY-143259

BE1218	LXR	Cancer
BE1218 is a liver X receptor (LXR) inverse agonist with IC₅₀ values of 9 nM and 7 nM against LXRα and LXRβ, respectively .

HY-16972

SR9243 5 Publications Verification	LXR	Cancer
SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.

HY-N2273

Gymnestrogenin	LXR	Metabolic Disease
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br . Gymnestrogenin is a *LXR* antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression .

HY-160038

GAC0003A4	LXR	Cancer
GAC0003A4 is an *LXR* inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies .

HY-170570

PFM046	LXR Stearoyl-CoA Desaturase (SCD) Fatty Acid Synthase (FASN)	Cancer
PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC₅₀ of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models .

HY-123402

GSK3987 1 Publications Verification	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation .

HY-N3216

Nagilactone B	LXR	Cardiovascular Disease
Nagilactone B is a liver X receptor (LXR) agonist.

HY-129098

DMHCA 1 Publications Verification	LXR	Metabolic Disease
DMHCA, a potent and selective *LXR* agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects?and can be used for the research of cholesterol homeostasis diabetes .

HY-101973

XL041 BMS-852927	LXR	Cardiovascular Disease
XL041 (BMS-852927) is an LXRβ-selective agonist.

HY-18282

AZ876	LXR	Cancer
AZ876 is a potent and high-affinity *LXR* agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively .

HY-112813

TUG-1375 3 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pK_i of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ .

HY-109073

Rovazolac ALX-101	LXR	Inflammation/Immunology
Rovazolac is a liver x receptor (LXR) modulator extracted from patent WO2013130892A1.

HY-123148

IMB-808	LXR	Inflammation/Immunology
IMB-808 is a potent LXRα/β dual agonist with EC₅₀ values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research .

HY-D1734

FITC-GW3965	LXR	Cardiovascular Disease
FITC-GW3965 is a fluorescence-labelled liver X receptor β (LXRβ) agonist GW3965 (HY-10627). FITC-GW3965 is a tracer, that can be designed by replacing the trifluoromethyl of GW3965 with an amide to link the FITC. FITC-GW3965 can be used to study the function of LXRβ .

HY-111498

RGX-104 hydrochloride 2 Publications Verification Abequolixron hydrochloride	LXR	Inflammation/Immunology Cancer
RGX-104 hydrochloride is a small-molecule *LXR* agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-154928

GW6340	LXR	Metabolic Disease
GW6340 is an intestinal-specific *LXR* agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT) .

HY-N12619

12R,13S-Dihydroxyfumitremorgin C	LXR	Cancer
12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist .

HY-133830

7α,24(S)-Dihydroxycholesterol (3β,7α,24S)-Cholest-5-ene-3,7,24-triol	Endogenous Metabolite	Others
7α,24(S)-Dihydroxycholesterol ((3β,7α,24S)-Cholest-5-ene-3,7,24-triol) serves as a ligand for liver X receptor (LXR), binding specifically to the ligand binding domains of both LXRα and LXRβ. This compound is synthetically produced from E-α,β-enone, utilizing Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde as starting materials, followed by a series of transformations to yield 7α,24(S)-dihydroxycholesterol.

HY-10626

T0901317 Maximum Cited Publications 28 Publications Verification	LXR FXR ROR Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
T0901317 is an orally active and highly selective *LXR* agonist with an EC₅₀ of 20 nM for LXRα . T0901317 activates FXR with an EC₅₀ of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .

HY-N2370

24-Hydroxycholesterol 1 Publications Verification	iGluR LXR	Neurological Disease
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors *LXR*.

HY-111498A

RGX-104 2 Publications Verification Abequolixron	LXR	Inflammation/Immunology Cancer
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor *(LXR)* agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-10627A

GW3965 hydrochloride 10+ Cited Publications	LXR	Cardiovascular Disease Cancer
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

HY-10627

GW3965	LXR	Cardiovascular Disease
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

HY-N1178

Taraxasterol 1 Publications Verification	Interleukin Related LXR	Inflammation/Immunology
Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases .

HY-125772

Acetyl podocarpic acid anhydride Acetylpodocarpic dimer; APD	LXR	Cardiovascular Disease
Acetyl podocarpic acid anhydride is a potent, semisynthetic *liver X receptor(LXR)* agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels .

HY-139067

25(S)-27-Hydroxy cholesterol	LXR	Cardiovascular Disease
25(S)-27-Hydroxy cholesterol is a metabolite of CYP27A1 mediated cholesterol hydroxylation. 25(S)-27-Hydroxy cholesterol inhibits melanoma cell proliferation .

HY-128671

6-Thioinosine 6TI; 6-Mercaptopurine riboside	Nucleoside Antimetabolite/Analog	Metabolic Disease
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Cardiovascular Disease Endocrinology Cancer
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-139576

Larsucosterol DUR-928	Endogenous Metabolite	Metabolic Disease
Larsucosterol (DUR-928), a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol as a potent endogenous regulator decreases lipogenesis. Larsucosterol inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-139576A

Larsucosterol sodium DUR-928 sodium	Endogenous Metabolite	Metabolic Disease
Larsucosterol (DUR-928) sodium, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol sodium as a potent endogenous regulator decreases lipogenesis. Larsucosterol sodium inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-N1178R

Taraxasterol (Standard)	Others Interleukin Related LXR	Inflammation/Immunology
Taraxasterol (Standard) is the analytical standard of Taraxasterol. This product is intended for research and analytical applications. Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases .

HY-139576B

Larsucosterol (trimethylamine) DUR-928 (trimethylamine)	LXR Endogenous Metabolite	Metabolic Disease
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1 .

HY-138007

SR-1903	ROR PPAR LXR	Metabolic Disease Inflammation/Immunology
SR-1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a *LXR* agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701404

	LXR-α Protein, Human NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3	Human	E. coli
	LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human is the recombinant human-derived LXR-α protein, expressed by E. coli , with tag free. The total length of LXR-α Protein, Human is 266 a.a., .

HY-P701405

	LXR-α Protein, Human (His) NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3	Human	E. coli
	LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human (His) is the recombinant human-derived LXR-α protein, expressed by E. coli , with N-6*His labeled tag. The total length of LXR-α Protein, Human (His) is 266 a.a., .

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HY-P80423

	LXR alpha Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	LXR alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to LXR alpha. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

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