2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. LXR agonist 1

LXR (Liver X receptor) agonist 1 is potent LXR agonist with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis.

For research use only. We do not sell to patients.

LXR agonist 1 Chemical Structure

LXR agonist 1 Chemical Structure

CAS No. : 1779524-90-1

Size Price Stock Quantity
5 mg USD 576 In-stock
10 mg USD 925 In-stock
25 mg USD 1845 In-stock
50 mg USD 2950 In-stock
100 mg USD 4130 In-stock
200 mg   Get quote  
500 mg   Get quote  

Get it by tomorrow April 22 for select sizes. Order within 7 hrs 35 mins.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LXR (Liver X receptor) agonist 1 is potent LXR agonist with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis[1].

IC50 & Target

AC50: 1.5 nM (LXR-α); 12 nM (LXR-β)[1]
In Vitro

LXR agonist 1 (compound 3) shows binding affinities with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

529.57

Formula

C27H26F3N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC1=C(C2=CC=CC(OC3=CC(S(N(C)CCN)(=O)=O)=CC=C3)=C2)C4=CC=CC(C(F)(F)F)=C4N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (330.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8883 mL 9.4416 mL 18.8832 mL
5 mM 0.3777 mL 1.8883 mL 3.7766 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8883 mL 9.4416 mL 18.8832 mL 47.2081 mL
5 mM 0.3777 mL 1.8883 mL 3.7766 mL 9.4416 mL
10 mM 0.1888 mL 0.9442 mL 1.8883 mL 4.7208 mL
15 mM 0.1259 mL 0.6294 mL 1.2589 mL 3.1472 mL
20 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3604 mL
25 mM 0.0755 mL 0.3777 mL 0.7553 mL 1.8883 mL
30 mM 0.0629 mL 0.3147 mL 0.6294 mL 1.5736 mL
40 mM 0.0472 mL 0.2360 mL 0.4721 mL 1.1802 mL
50 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL
60 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7868 mL
80 mM 0.0236 mL 0.1180 mL 0.2360 mL 0.5901 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4721 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LXR agonist 1 Related Classifications

Keywords:

LXR agonist 11779524-90-1LXR agonist1LXR agonist-1LXRLiver X receptorAtherosclerosisantibody-drug conjugatesimplified binding modelsuppress inflammationliverInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LXR agonist 1
Cat. No.:
HY-144549
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.