2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. LXR agonist 1

LXR (Liver X receptor) agonist 1 is potent LXR agonist with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis.

For research use only. We do not sell to patients.

LXR agonist 1 Chemical Structure

LXR agonist 1 Chemical Structure

CAS No. : 1779524-90-1

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Based on 1 publication(s) in Google Scholar

LXR agonist 1 Related Antibodies

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Description

LXR (Liver X receptor) agonist 1 is potent LXR agonist with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis[1].

IC50 & Target

AC50: 1.5 nM (LXR-α); 12 nM (LXR-β)[1]
In Vitro

LXR agonist 1 (compound 3) shows binding affinities with AC50s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LXR agonist 1 Related Antibodies
Molecular Weight

529.57

Formula

C27H26F3N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC1=C(C2=CC=CC(OC3=CC(S(N(C)CCN)(=O)=O)=CC=C3)=C2)C4=CC=CC(C(F)(F)F)=C4N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (330.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8883 mL 9.4416 mL 18.8832 mL
5 mM 0.3777 mL 1.8883 mL 3.7766 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8883 mL 9.4416 mL 18.8832 mL 47.2081 mL
5 mM 0.3777 mL 1.8883 mL 3.7766 mL 9.4416 mL
10 mM 0.1888 mL 0.9442 mL 1.8883 mL 4.7208 mL
15 mM 0.1259 mL 0.6294 mL 1.2589 mL 3.1472 mL
20 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3604 mL
25 mM 0.0755 mL 0.3777 mL 0.7553 mL 1.8883 mL
30 mM 0.0629 mL 0.3147 mL 0.6294 mL 1.5736 mL
40 mM 0.0472 mL 0.2360 mL 0.4721 mL 1.1802 mL
50 mM 0.0378 mL 0.1888 mL 0.3777 mL 0.9442 mL
60 mM 0.0315 mL 0.1574 mL 0.3147 mL 0.7868 mL
80 mM 0.0236 mL 0.1180 mL 0.2360 mL 0.5901 mL
100 mM 0.0189 mL 0.0944 mL 0.1888 mL 0.4721 mL
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LXR agonist 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXR agonist 11779524-90-1LXR agonist1LXR agonist-1LXRLiver X receptorAtherosclerosisantibody-drug conjugatesimplified binding modelsuppress inflammationliverInhibitorinhibitorinhibit

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LXR agonist 1
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