2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. Interleukin Related LXR
  4. Taraxasterol

Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases.

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Taraxasterol Chemical Structure

Taraxasterol Chemical Structure

CAS No. : 1059-14-9

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5 mg USD 65 In-stock
10 mg USD 105 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Taraxasterol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Taraxasterol

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3].

In Vitro

Taraxasterol (5-18 μg/ml, 1 h) inhibits vascular inflammation in human umbilical vein endothelial cells by activating LXRα [3].
Taraxasterol (2.5-10 μg/ml, 24 h) exhibits anti-inflammatory effects on human osteoarthritic chondrocytes [5].
Taraxasterol (114.68 μM, 24 h) has anti-metastatic effects on prostate cancer cells [6].
Taraxasterol (5-18 μg/ml, 1 h) shows no cytotoxicity to human umbilical vein endothelial cells at concentrations below 15 μg/ml [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Taraxasterol Related Antibodies

Western Blot Analysis[5]

Cell Line: Human umbilical vein endothelial cells (HUVECs)
Concentration: 2.5, 5, 10 μg/ml
Incubation Time: 24 h
Result: Dose-dependently inhibited IL-1β-induced NF-κB activation.

Cell Viability Assay[3]

Cell Line: Human osteoarthritic chondrocytes
Concentration: 5-18 μg/ml
Incubation Time: 1 h
Result: Did not have cytotoxic effects on HUVECs at the concentrations of 5, 10, and 15 μg/ml.
Could decrease the viability of HUVECs at the concentration of 18 μg/ml.

Cell Viability Assay[6]

Cell Line: Prostate cancer cell lines (PC3 cells)
Concentration: 1, 2, 4, 8, 16, 32, 64, 128 μM
Incubation Time: 24, 48, 72 h
Result: Reduced the survival rate of PC3 cells.

Cell Invasion Assay[6]

Cell Line: Prostate cancer cell lines (PC3 cells)
Concentration: 114.68 μM
Incubation Time: 24 h
Result: Decreased the potential for cell invasion by 54%.
In Vivo

Taraxasterol (2.5, 5, and 10 mg/kg, i.p., 8 h) has a protective effect against acute lung injury in a lipopolysaccharide (HY-D1056)-induced acute lung injury mouse model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lipopolysaccharide (HY-D1056)-induced acute lung injury mouse model
Dosage: 2.5, 5, and 10 mg/kg
Administration: Intraperitoneal injection (i.p.), 8 h
Result: Inhibited the phosphorylation of IκB-α, p65 NF-κB, p46–p54 JNK, p42–p44 ERK, and p38 caused by Lipopolysaccharide (HY-D1056).
Molecular Weight

426.72

Formula

C30H50O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)([C@]1([H])CC[C@@]([C@](CC[C@@](CC2)3C)4C)5C)[C@@H](O)CC[C@]1(C)[C@@]5([H])CC[C@]4([H])[C@@]3([H])[C@H](C)C2=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 4 mg/mL (9.37 mM; Need ultrasonic)

DMSO : 1 mg/mL (2.34 mM; ultrasonic and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.55 mg/mL (1.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.55 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (5.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 0.55 mg/mL (1.29 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.55 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (5.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.41%

COA (252 KB) HNMR (452 KB) RP-HPLC (220 KB) MS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
Ethanol 5 mM 0.4687 mL 2.3435 mL 4.6869 mL 11.7173 mL
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Taraxasterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taraxasterol1059-14-9Interleukin RelatedLXRILLiver X receptorInhibitorinhibitorinhibit

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